Optical coherence tomography angiography of astrocytic hamartoma demonstrates intrinsic vascularity

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Purpose: To evaluate the findings of astrocytic hamartoma in the setting of gyrate atrophy, including details of optical coherence tomography angiography (OCTA). Observations: Multimodal imaging was obtained on a 20-year-old woman with genetically-confirmed gyrate atrophy. Dilated fundus exam was performed, followed by ultra-widefield color and green autofluorescence imaging and OCTA of bilateral peripapillary and optic disc lesions. Clinical and imaging findings were consistent with gyrate atrophy. The bilateral peripapillary and optic disc lesions had a glistening, translucent, and mulberry-like appearance. OCTA imaging of these lesions clearly demonstrated an intrinsic vascular network and hyporeflective spaces within the lesion, which could not be seen on routine examination. Conclusions and importance: OCTA was used to noninvasively diagnose astrocytic hamartoma in this patient with gyrate atrophy by showing the intrinsic vasculature and hyporeflective spaces of the lesion. This imaging modality can help differentiate astrocytic hamartoma from other lesions that typically lack intrinsic vascularity, such as optic disc drusen.

Original languageEnglish (US)
Article number100924
JournalAmerican Journal of Ophthalmology Case Reports
StatePublished - Dec 2020


  • Astrocytic hamartoma
  • Gyrate atrophy
  • Intrinsic vascularity
  • Optical coherence tomography angiography

ASJC Scopus subject areas

  • Ophthalmology


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