Optic Disc Edema in Raised Intracranial Pressure: IV. Axoplasmic Transport in Experimental Papilledema

Mark O.M. Tso, Sohan Singh Hayreh

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138 Scopus citations


Tritiated leucine was Injected intravitreously into the eyes of rhesus monkeys that had developed papilledema secondary to implantation of intracranial balloons. Autoradiographic studies of the optic nerve head showed that six hours after intravitreous injection of the isotope the fast component of axoplasmic transport accumulated in the regions of the lamina choroidalis and lamina scleralis. The slow component arrived at the optic nerve head two to four days after injection, and the swollen axons of the entire optic nerve head were filled with radioactive isotopes. Twelve days after injection of isotope, the axons in the optic nerve head were still diffusely labeled. Disturbance of axoplasmic transport was one of the primary events resulting in swelling of axons in papilledema. The pattern of axoplasmic disturbances in papilledema secondary to raised intracranial pressure was similar to that observed in papilledema secondary to ocular hypotony or increased intraocular pressure. Ocular hypotony, raised intracranial pressure, and increased intraocular pressure appear to share a final common pathway. All these conditions apparently converge into this final common pathway of disturbance of axoplasmic transport to give rise to papilledema.

Original languageEnglish (US)
Pages (from-to)1458-1462
Number of pages5
JournalArchives of ophthalmology
Issue number8
StatePublished - Aug 1977
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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