Opposing effects of retinoid signaling on astrogliogenesis in embryonic day 13 and 17 cortical progenitor cells

Roland Faigle, Lidong Liu, Paige Cundiff, Keiko Funa, Zhengui Xia

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


All-trans retinoic acid (RA) is a differentiation factor in many tissues. However, its role in astrogliogenesis has not been extensively studied. Here, we investigated the effect of RA on the regulation of astrogliogenesis at different cortical developmental stages. We prepared rat cortical progenitor cells from embryonic day (E) 13 and E17, which correspond to the beginning of neurogenic and astrogliogenic periods, respectively. Surprisingly, RA promoted astrogliogenesis at E17 but inhibited astrogliogenesis induced by ciliary neurotrophic factor (CNTF) at E13. The inhibitory effect of RA on astrogliogenesis at E13 was not due to premature commitment of progenitors to a neuronal or oligodendroglial lineage. Rather, RA retained more progenitors in a proliferative state. Furthermore, RA inhibition of astrogliogenesis at E13 was independent of STAT3 signaling and required the function of the α and β isoforms of the RA receptors (RAR). Moreover, the differential response of E13 and E17 progenitors to RA was due to differences in the intrinsic properties of these cells that are preserved in vitro. The inhibitory effect of RA on cytokine-induced astrogliogenesis at E13 may contribute to silencing of any potential precocious astrogliogenesis during the neurogenic period.

Original languageEnglish (US)
Pages (from-to)1681-1698
Number of pages18
JournalJournal of Neurochemistry
Issue number4
StatePublished - Aug 2008
Externally publishedYes


  • CNTF
  • Glial differentiation
  • Gliogenesis
  • Neural stem cell
  • Neurogenesis
  • Retinoic acid

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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