Opportunities in precision psychiatry using PET neuroimaging in psychosis

Jennifer M. Coughlin; Andrew G. Horti; Martin G. Pomper

doi:10.1016/j.nbd.2019.03.016

Opportunities in precision psychiatry using PET neuroimaging in psychosis

Jennifer M. Coughlin, Andrew G. Horti, Martin G. Pomper

School of Medicine

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

With the movement toward precision medicine in healthcare, recent studies of individuals with psychosis have begun to explore positron emission tomography (PET) as a tool to test for biochemical signatures that may distinguish subtypes of psychosis that guide subtype-specific therapeutic interventions. This review presents selected PET findings that exemplify early promise in using molecular imaging to predict treatment response, provide rationale for new therapeutic targets, and monitor target engagement in biomarker-defined subtypes of psychosis. PET data, among other data types, may prove useful in the scientific pursuit of identifying precision strategies to improve clinical outcomes for individuals with psychosis.

Original language	English (US)
Article number	104428
Journal	Neurobiology of Disease
Volume	131
DOIs	https://doi.org/10.1016/j.nbd.2019.03.016
State	Published - Nov 2019

Keywords

Dopamine
Neuroimmunity
PET imaging
Precision medicine
Psychosis
alpha7 nicotinic acetylcholine receptor

ASJC Scopus subject areas

Neurology

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10.1016/j.nbd.2019.03.016

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@article{bfeb518f47b8495c9133d4a6a9b14d35,

title = "Opportunities in precision psychiatry using PET neuroimaging in psychosis",

abstract = "With the movement toward precision medicine in healthcare, recent studies of individuals with psychosis have begun to explore positron emission tomography (PET) as a tool to test for biochemical signatures that may distinguish subtypes of psychosis that guide subtype-specific therapeutic interventions. This review presents selected PET findings that exemplify early promise in using molecular imaging to predict treatment response, provide rationale for new therapeutic targets, and monitor target engagement in biomarker-defined subtypes of psychosis. PET data, among other data types, may prove useful in the scientific pursuit of identifying precision strategies to improve clinical outcomes for individuals with psychosis.",

keywords = "Dopamine, Neuroimmunity, PET imaging, Precision medicine, Psychosis, alpha7 nicotinic acetylcholine receptor",

author = "Coughlin, {Jennifer M.} and Horti, {Andrew G.} and Pomper, {Martin G.}",

note = "Funding Information: This work was supported by the Alexander Wilson Schweizer Fellowship, a Johns Hopkins Doris Duke Foundation Early Clinician Investigator Award, the Ryan Licht Sang Bipolar Foundation, and EB024495. The authors declare no conflicts of interest. Funding Information: This work was supported by the Alexander Wilson Schweizer Fellowship , a Johns Hopkins Doris Duke Foundation Early Clinician Investigator Award , the Ryan Licht Sang Bipolar Foundation , and EB024495. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = nov,

doi = "10.1016/j.nbd.2019.03.016",

language = "English (US)",

volume = "131",

journal = "Neurobiology of Disease",

issn = "0969-9961",

publisher = "Academic Press Inc.",

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T1 - Opportunities in precision psychiatry using PET neuroimaging in psychosis

AU - Coughlin, Jennifer M.

AU - Horti, Andrew G.

AU - Pomper, Martin G.

N1 - Funding Information: This work was supported by the Alexander Wilson Schweizer Fellowship, a Johns Hopkins Doris Duke Foundation Early Clinician Investigator Award, the Ryan Licht Sang Bipolar Foundation, and EB024495. The authors declare no conflicts of interest. Funding Information: This work was supported by the Alexander Wilson Schweizer Fellowship , a Johns Hopkins Doris Duke Foundation Early Clinician Investigator Award , the Ryan Licht Sang Bipolar Foundation , and EB024495. Publisher Copyright: © 2019 Elsevier Inc.

PY - 2019/11

Y1 - 2019/11

N2 - With the movement toward precision medicine in healthcare, recent studies of individuals with psychosis have begun to explore positron emission tomography (PET) as a tool to test for biochemical signatures that may distinguish subtypes of psychosis that guide subtype-specific therapeutic interventions. This review presents selected PET findings that exemplify early promise in using molecular imaging to predict treatment response, provide rationale for new therapeutic targets, and monitor target engagement in biomarker-defined subtypes of psychosis. PET data, among other data types, may prove useful in the scientific pursuit of identifying precision strategies to improve clinical outcomes for individuals with psychosis.

AB - With the movement toward precision medicine in healthcare, recent studies of individuals with psychosis have begun to explore positron emission tomography (PET) as a tool to test for biochemical signatures that may distinguish subtypes of psychosis that guide subtype-specific therapeutic interventions. This review presents selected PET findings that exemplify early promise in using molecular imaging to predict treatment response, provide rationale for new therapeutic targets, and monitor target engagement in biomarker-defined subtypes of psychosis. PET data, among other data types, may prove useful in the scientific pursuit of identifying precision strategies to improve clinical outcomes for individuals with psychosis.

KW - Dopamine

KW - Neuroimmunity

KW - PET imaging

KW - Precision medicine

KW - Psychosis

KW - alpha7 nicotinic acetylcholine receptor

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DO - 10.1016/j.nbd.2019.03.016

M3 - Review article

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SN - 0969-9961

VL - 131

JO - Neurobiology of Disease

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ER -

Opportunities in precision psychiatry using PET neuroimaging in psychosis

Abstract

Keywords

ASJC Scopus subject areas

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