@article{b4ea43295e6940a8a8db14649920edb5,
title = "Opportunities and challenges for junior investigators conducting pain clinical trials",
abstract = "Introduction:Clinical investigation serves a vital role to advance treatment and management strategies for patients with pain. For those new to clinical investigation, key advice for both the novice clinical investigator and the experienced researcher expanding to translational work may accelerate research efforts.Objective:To review foundational material relevant to junior investigators focusing on pain clinical trials, with an emphasis on randomized controlled trials.Methods:We reviewed recent publications and resources relevant to clinical investigators, with a particular emphasis on pain research.Results:Understanding the approaches and barriers to clinical pain research is a first step to building a successful investigative portfolio. Key components of professional development include motivation, mentorship, and collaborative approaches to research. Many junior clinical investigators face challenges in pursing research careers and sparking iterative progress toward success in clinical trials. Pain-specific research metrics and goals - including hypothesis development, study design considerations, and regulatory concerns - are also important considerations to junior investigators who pursue clinical trails. Approaches to build toward collaborative and independent funding are essential for investigators.Conclusion:This work provides a foundation for understanding the clinical research process and helps inform the goals and plans of clinical investigators.",
keywords = "Clinical protocol, Clinical trial, Pain, Pain measurement, Research design, Sample size",
author = "Adams, {Meredith C.B.} and Bicket, {Mark C.} and Murphy, {Jamie D.} and Wu, {Christopher L.} and Hurley, {Robert W.}",
note = "Funding Information: Informatics for Integrating Biology and the Bedside (i2b2) Institutional Review Board and regulatory components Collaborative Institutional Training Initiative (CITI) Program Special consideration for studying pain NIH Interagency Committee{\textquoteright}s National Pain Strategy Canadian Institutes of Health Research Institute of Musculoskeletal Health and Arthritis Study protocol and national trial registration How to register your study at ClinicalTrials.gov International Clinical Trials Registry Platform How to write a research project grant application Funding Patient-Centered Outcomes Research Institute (PRCORI) Agency for Healthcare Research and Quality Department of Defense (DOD) Additional resources Pain Research Forum International Association for the Study of Pain{\textquoteright}s Pain Schools and Camps Funding Information: Traditionally focused on the NIH, many institutions are recognizing the value of other federal granting sources such as PCORI (http://www.pcori.org/), Agency for Healthcare Research and Quality (http://www.ahrq.gov/), and DOD (http://cdmrp.army.mil/). These granting bodies represent different scientific perspectives with specific foci. Reading about the missions and approaches will help direct your work to the best home. Understanding that granting organizations have specific portfolio needs is the first step to finding the best fit for your idea. Many of the federal agencies have career development grants (VHA, NIH, Agency for Healthcare Research and Quality), and these have defined program officers who help manage these grants. These program officers can have helpful advice about whether your idea fits within the scope of their group, and it is worth the effort to determine whether their agency will be interested in funding your idea. Even the highest scoring grant will not be funded if it does not align with the goals of the funding organization. Program officers can and will direct you to a better fit if they feel that this is appropriate and can also make suggestions to strengthen your application, so speak with them early and often if possible. The benefit of these grants is the protected time to focus on your research and career development. Publisher Copyright: {\textcopyright} 2019 The Author(s).",
year = "2019",
month = may,
day = "1",
doi = "10.1097/PR9.0000000000000639",
language = "English (US)",
volume = "4",
journal = "Pain Reports",
issn = "2471-2531",
publisher = "Lippincott Williams and Wilkins",
number = "3",
}