Opioidergic and dopaminergic gene expression in the caudate-putamen and accumbens of the mutant mouse, tottering (tg/tg)

Andrea De Bartolomeis; Vuk Koprivica; David Pickar; Jacqueline N. Crawley; Louise C. Abbott

doi:10.1016/S0169-328X(97)00027-2

Opioidergic and dopaminergic gene expression in the caudate-putamen and accumbens of the mutant mouse, tottering (tg/tg)

Andrea De Bartolomeis, Vuk Koprivica, David Pickar, Jacqueline N. Crawley, Louise C. Abbott

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Expression of preproenkephalin, dynorphin and D₂ dopamine receptor mRNAs was examined in selected regions of the forebrain of homozygous and heterozygous tottering mice, using in situ hybridization histochemistry. Homozygous tottering mice carry an autosomal recessive mutation causing them to exhibit petit mal-like epilepsy. Preproenkephalin mRNA levels were significantly higher in the lateral caudate and the core of the nucleus accumbens of homozygous tottering mice compared to wild-type controls. No differences were observed in the expression of dynorphin and D₂ receptor mRNA distribution in brain regions examined in the mutant mice as compared to wild-type controls.

Original language	English (US)
Pages (from-to)	321-324
Number of pages	4
Journal	Molecular Brain Research
Volume	46
Issue number	1-2
DOIs	https://doi.org/10.1016/S0169-328X(97)00027-2
State	Published - Jun 1997
Externally published	Yes

Keywords

D dopamine receptor
Dynorphin
Enkephalin
Epilepsy
Hybridization histochemistry, in situ
mRNA
Striatum

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/S0169-328X(97)00027-2

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title = "Opioidergic and dopaminergic gene expression in the caudate-putamen and accumbens of the mutant mouse, tottering (tg/tg)",

abstract = "Expression of preproenkephalin, dynorphin and D2 dopamine receptor mRNAs was examined in selected regions of the forebrain of homozygous and heterozygous tottering mice, using in situ hybridization histochemistry. Homozygous tottering mice carry an autosomal recessive mutation causing them to exhibit petit mal-like epilepsy. Preproenkephalin mRNA levels were significantly higher in the lateral caudate and the core of the nucleus accumbens of homozygous tottering mice compared to wild-type controls. No differences were observed in the expression of dynorphin and D2 receptor mRNA distribution in brain regions examined in the mutant mice as compared to wild-type controls.",

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T1 - Opioidergic and dopaminergic gene expression in the caudate-putamen and accumbens of the mutant mouse, tottering (tg/tg)

AU - De Bartolomeis, Andrea

AU - Koprivica, Vuk

AU - Pickar, David

AU - Crawley, Jacqueline N.

AU - Abbott, Louise C.

PY - 1997/6

Y1 - 1997/6

N2 - Expression of preproenkephalin, dynorphin and D2 dopamine receptor mRNAs was examined in selected regions of the forebrain of homozygous and heterozygous tottering mice, using in situ hybridization histochemistry. Homozygous tottering mice carry an autosomal recessive mutation causing them to exhibit petit mal-like epilepsy. Preproenkephalin mRNA levels were significantly higher in the lateral caudate and the core of the nucleus accumbens of homozygous tottering mice compared to wild-type controls. No differences were observed in the expression of dynorphin and D2 receptor mRNA distribution in brain regions examined in the mutant mice as compared to wild-type controls.

AB - Expression of preproenkephalin, dynorphin and D2 dopamine receptor mRNAs was examined in selected regions of the forebrain of homozygous and heterozygous tottering mice, using in situ hybridization histochemistry. Homozygous tottering mice carry an autosomal recessive mutation causing them to exhibit petit mal-like epilepsy. Preproenkephalin mRNA levels were significantly higher in the lateral caudate and the core of the nucleus accumbens of homozygous tottering mice compared to wild-type controls. No differences were observed in the expression of dynorphin and D2 receptor mRNA distribution in brain regions examined in the mutant mice as compared to wild-type controls.

KW - D dopamine receptor

KW - Dynorphin

KW - Enkephalin

KW - Epilepsy

KW - Hybridization histochemistry, in situ

KW - mRNA

KW - Striatum

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ER -

Opioidergic and dopaminergic gene expression in the caudate-putamen and accumbens of the mutant mouse, tottering (tg/tg)

Abstract

Keywords

ASJC Scopus subject areas

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