Opiate analgesia: Evidence for mediation by a subpopulation of opiate receptors

Gavril W. Pasternak, Stephen R. Childers, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

195 Scopus citations


Naloxazone, a hydrazone derivative of the opiate antagonist naloxone, has a high affinity for opiate receptor binding sites. Naloxazone injections reduce opiate receptor binding to extensively washed mouse brain membranes for more than 24 hours, suggesting that the effect is irreversible. High-affinity binding sites are abolished by this treatment, whereas low-affinity sites are unaffected. Naloxazone treatment blocks the analgesic effects of morphine for at least 24 hours but does not prevent death from high doses of morphine. Thus analgesic but nonlethal opiate effects may be mediated by the high-affinity subpopulation of opiate receptors.

Original languageEnglish (US)
Pages (from-to)516-518
Number of pages3
Issue number4443
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Opiate analgesia: Evidence for mediation by a subpopulation of opiate receptors'. Together they form a unique fingerprint.

Cite this