One year follow-up of taste-related reward associations with weight loss suggests a critical time to mitigate weight regain following bariatric surgery

Kimberly R. Smith, Anahys Aghababian, Afroditi Papantoni, Maria G. Veldhuizen, Vidyulata Kamath, Civonnia Harris, Timothy H. Moran, Susan Carnell, Kimberley E. Steele

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Weight regain is a concerning issue in bariatric patients. We previously demonstrated that taste-related reward processing was associated with six-month weight loss outcomes following Roux-en-Y gastric bypass (RYGB) but not vertical sleeve gastrectomy (VSG). Here, we assessed whether these taste factors persisted in predicting weight loss, and weight regain, at one year post-surgery. Methods: Adult women enrolled in a longitudinal study of taste preferences following bariatric surgery completed behavioral and neuroimaging assessments at one year postsurgery. Results: RYGB produced better weight loss relative to VSG, with weight regain and greater weight loss variability observed from six months to one year post-VSG. Changes in liking for high fat at 2 weeks post-surgery from baseline remained a predictor of weight loss in RYGB, but other predictors did not persist. Average liking ratings rebounded to baseline and higher self-reported food cravings and dietary disinhibition correlated with poorer weight loss at one year post-surgery. Conclusion: Initial anatomical and metabolic changes resulting from RYGB that reset neural processing of reward stimuli in the mesolimbic pathway appear to be temporary and may be contingent upon post-operative eating behaviors returning to preoperative obesogenic tendencies. Six months post-surgery may be a critical window for implementing interventions to mitigate weight gain.

Original languageEnglish (US)
Article number3943
JournalNutrients
Volume13
Issue number11
DOIs
StatePublished - Nov 2021

Keywords

  • Bariatric surgery
  • Reward
  • Roux-en-Y gastric bypass
  • Taste
  • Vertical sleeve gastrectomy
  • Weight loss

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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