One Actor, Many Roles: Histopathologies Associated with APOL1 Genetic Variants

Jeffrey B. Kopp, Avi Z. Rosenberg

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Genetic variants in APOL1, encoding apolipoprotein L1, are major drivers of glomerular disease in peoples of sub-Saharan African descent. APOL1-associated primary glomerular diseases include focal segmental glomerulosclerosis, human immunodeficiency virus-associated nephropathies, and arterionephrosclerosis. Other conditions where APOL1 variants affect outcomes include membranous nephropathy, lupus nephritis, diabetic nephropathy, preeclampsia, and kidney transplant. In focal segmental glomerulosclerosis, APOL1 variants are associated with upregulation of RNA encoding chemokine C-X-C motif receptor 3 ligands and ubiquitin D; the significance of these findings remains unclear but may provide valuable insight into disease mechanisms.

Original languageEnglish (US)
Pages (from-to)215-219
Number of pages5
JournalAdvances in anatomic pathology
Issue number3
StatePublished - May 1 2019


  • APOL1
  • arterionephrosclerosis
  • collapsing glomerulopathy
  • focal segmental glomerulosclerosis
  • genetic

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine


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