On the development of biophysical models for space radiation risk assessment

F. A. Cucinotta, J. F. Dicello

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Experimental techniques in molecular biology are being applied to study biological risks from space radiation. The use of molecular assays presents a challenge to biophysical models which in the past have relied on descriptions of energy deposition and phenomenological treatments of repair. We describe a biochemical kinetics model of cell cycle control and DNA damage response proteins in order to model cellular responses to radiation exposures. Using models of cyclin-cdk, pRB, E2F's, p53, and G1 inhibitors we show that simulations of cell cycle populations and G1 arrest can be described by our biochemical approach. We consider radiation damaged DNA as a substrate for signal transduction processes and consider a dose and dose-rate reduction effectiveness factor (DDREF) for protein expression.

Original languageEnglish (US)
Pages (from-to)2131-2140
Number of pages10
JournalAdvances in Space Research
Issue number10
StatePublished - May 2000

ASJC Scopus subject areas

  • Aerospace Engineering
  • Astronomy and Astrophysics
  • Geophysics
  • Atmospheric Science
  • Space and Planetary Science
  • Earth and Planetary Sciences(all)


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