On estimating HLA/disease association with application to a study of aplastic anemia

S. G. Self; G. Longton; K. J. Kopecky; K. Y. Liang

doi:10.2307/2532495

On estimating HLA/disease association with application to a study of aplastic anemia

S. G. Self, G. Longton, K. J. Kopecky, K. Y. Liang

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140 Scopus citations

Abstract

A multiplicative model is described relating HLA typing information to disease incidence. A likelihood-based method for estimating parameters in this model is proposed for use with data sets in which HLA haplotype information is available on a series of cases and their parents. This approach is extended to incorporate information from a matched control series for the purpose of estimating HLA and environmental risk factor effects simultaneously. The method is applied to data from aplastic anemia patients treated by bone marrow transplantation and the results are compared to unmatched case-control analyses using the same case series and several different control series.

Original language	English (US)
Pages (from-to)	53-61
Number of pages	9
Journal	Biometrics
Volume	47
Issue number	1
DOIs	https://doi.org/10.2307/2532495
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Statistics and Probability
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)
Applied Mathematics

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10.2307/2532495

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Y1 - 1991

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AB - A multiplicative model is described relating HLA typing information to disease incidence. A likelihood-based method for estimating parameters in this model is proposed for use with data sets in which HLA haplotype information is available on a series of cases and their parents. This approach is extended to incorporate information from a matched control series for the purpose of estimating HLA and environmental risk factor effects simultaneously. The method is applied to data from aplastic anemia patients treated by bone marrow transplantation and the results are compared to unmatched case-control analyses using the same case series and several different control series.

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On estimating HLA/disease association with application to a study of aplastic anemia

Abstract

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