On and off: Proteasome and TGF-β signaling

Fan Zhang, Marikki Laiho

Research output: Contribution to journalShort surveypeer-review

50 Scopus citations

Abstract

Transforming growth factor-β (TGF-β) signaling mainly relies on the TGF-β receptor-Smad pathway. Meanwhile, TGF-β binding to its receptors initiates the degradation of several key components of its signaling pathway. The degradation of these components, including both positive and negative transducers, is mediated by the ubiquitin-proteasome system. Inhibition of the proteasome activity causes accumulation of these components in the cells and modulates TGF-β signaling in a time-dependent and gene-specific manner. The accelerated degradation of TGF-β signaling components via the proteasome system has been found in a number of tumors, indicating that dysregulated proteasomal degradation is a novel pathway how tumor cells silence TGF-β signaling.

Original languageEnglish (US)
Pages (from-to)275-281
Number of pages7
JournalExperimental cell research
Volume291
Issue number2
DOIs
StatePublished - Dec 1 2003
Externally publishedYes

Keywords

  • Proteasome
  • Receptors
  • Signaling
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Cell Biology

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