Olfactory Testing in Temporal Lobe Epilepsy: a Systematic Review

Brian Y. Hwang, David Mampre, Rachel Penn, William S. Anderson, Joon Kang, Vidyulata Kamath

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: Olfactory testing is a potentially safe, cost-effective, bedside evaluation tool for diagnosis, monitoring, and risk assessment for surgery in temporal lobe epilepsy (TLE) patients, but testing methods and relevant olfactory domains are not standardized. We conducted a systematic review to evaluate olfactory tests in TLE and summarize the results of the literature. Recent Findings: Olfactory tests varied significantly in odorant administration tools and devices, target odorants, evaluation timing, and grading scales. The Smell Threshold Test and University of Pennsylvania Smell Identification Test were the most validated single-domain tests for odor detection and odor identification, respectively. For multi-domain tests, Odor Memory/Discrimination Test and the Sniffin’ Sticks test were the most validated. Results of olfactory tests in TLE are presented by domain. Summary: Rigorous validation, standardization, and comparative analysis of existing olfactory tests by domain is urgently needed to establish the utility and efficacy of olfactory testing in TLE.

Original languageEnglish (US)
Article number65
JournalCurrent neurology and neuroscience reports
Issue number12
StatePublished - Dec 2020


  • Complex partial seizures
  • Mesial temporal lobe
  • Olfactory testing
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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