TY - JOUR
T1 - Olfactory Testing in Temporal Lobe Epilepsy
T2 - a Systematic Review
AU - Hwang, Brian Y.
AU - Mampre, David
AU - Penn, Rachel
AU - Anderson, William S.
AU - Kang, Joon
AU - Kamath, Vidyulata
N1 - Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/12
Y1 - 2020/12
N2 - Purpose of Review: Olfactory testing is a potentially safe, cost-effective, bedside evaluation tool for diagnosis, monitoring, and risk assessment for surgery in temporal lobe epilepsy (TLE) patients, but testing methods and relevant olfactory domains are not standardized. We conducted a systematic review to evaluate olfactory tests in TLE and summarize the results of the literature. Recent Findings: Olfactory tests varied significantly in odorant administration tools and devices, target odorants, evaluation timing, and grading scales. The Smell Threshold Test and University of Pennsylvania Smell Identification Test were the most validated single-domain tests for odor detection and odor identification, respectively. For multi-domain tests, Odor Memory/Discrimination Test and the Sniffin’ Sticks test were the most validated. Results of olfactory tests in TLE are presented by domain. Summary: Rigorous validation, standardization, and comparative analysis of existing olfactory tests by domain is urgently needed to establish the utility and efficacy of olfactory testing in TLE.
AB - Purpose of Review: Olfactory testing is a potentially safe, cost-effective, bedside evaluation tool for diagnosis, monitoring, and risk assessment for surgery in temporal lobe epilepsy (TLE) patients, but testing methods and relevant olfactory domains are not standardized. We conducted a systematic review to evaluate olfactory tests in TLE and summarize the results of the literature. Recent Findings: Olfactory tests varied significantly in odorant administration tools and devices, target odorants, evaluation timing, and grading scales. The Smell Threshold Test and University of Pennsylvania Smell Identification Test were the most validated single-domain tests for odor detection and odor identification, respectively. For multi-domain tests, Odor Memory/Discrimination Test and the Sniffin’ Sticks test were the most validated. Results of olfactory tests in TLE are presented by domain. Summary: Rigorous validation, standardization, and comparative analysis of existing olfactory tests by domain is urgently needed to establish the utility and efficacy of olfactory testing in TLE.
KW - Complex partial seizures
KW - Mesial temporal lobe
KW - Olfactory testing
KW - Temporal lobe epilepsy
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U2 - 10.1007/s11910-020-01083-x
DO - 10.1007/s11910-020-01083-x
M3 - Review article
C2 - 33169232
AN - SCOPUS:85095698893
SN - 1528-4042
VL - 20
JO - Current neurology and neuroscience reports
JF - Current neurology and neuroscience reports
IS - 12
M1 - 65
ER -