TY - JOUR
T1 - Olfactory modulation of the medial prefrontal cortex circuitry
T2 - Implications for social cognition
AU - Bhattarai, Janardhan P.
AU - Etyemez, Semra
AU - Jaaro-Peled, Hanna
AU - Janke, Emma
AU - Leon Tolosa, Usuy D.
AU - Kamiya, Atsushi
AU - Gottfried, Jay A.
AU - Sawa, Akira
AU - Ma, Minghong
N1 - Funding Information:
This work is supported by NIDCD ( R01DC006213 to MM, R21DC019193 to JPB, and R01DC018075 to JAG), NIMH ( P50MH094268 , R01MH105660 , and R01MH107730 to AS), NIDA ( R01DA049545 and R01DA049449 to MM, R01DA041208 to AK), NIA ( R01AG065168 to AK), and foundation grants from Stanley and RUSK/S-R (to AS).
Publisher Copyright:
© 2021
PY - 2022/9
Y1 - 2022/9
N2 - Olfactory dysfunction is manifested in a wide range of neurological and psychiatric diseases, and often emerges prior to the onset of more classical symptoms and signs. From a behavioral perspective, olfactory deficits typically arise in conjunction with impairments of cognition, motivation, memory, and emotion. However, a conceptual framework for explaining the impact of olfactory processing on higher brain functions in health and disease remains lacking. Here we aim to provide circuit-level insights into this question by synthesizing recent advances in olfactory network connectivity with other cortical brain regions such as the prefrontal cortex. We will focus on social cognition as a representative model for exploring and critically evaluating the relationship between olfactory cortices and higher-order cortical regions in rodent models. Although rodents do not recapitulate all dimensions of human social cognition, they have experimentally accessible neural circuits and well-established behavioral tests for social motivation, memory/recognition, and hierarchy, which can be extrapolated to other species including humans. In particular, the medial prefrontal cortex (mPFC) has been recognized as a key brain region in mediating social cognition in both rodents and humans. This review will highlight the underappreciated connectivity, both anatomical and functional, between the olfactory system and mPFC circuitry, which together provide a neural substrate for olfactory modulation of social cognition and social behaviors. We will provide future perspectives on the functional investigation of the olfactory-mPFC circuit in rodent models and discuss how to translate such animal research to human studies.
AB - Olfactory dysfunction is manifested in a wide range of neurological and psychiatric diseases, and often emerges prior to the onset of more classical symptoms and signs. From a behavioral perspective, olfactory deficits typically arise in conjunction with impairments of cognition, motivation, memory, and emotion. However, a conceptual framework for explaining the impact of olfactory processing on higher brain functions in health and disease remains lacking. Here we aim to provide circuit-level insights into this question by synthesizing recent advances in olfactory network connectivity with other cortical brain regions such as the prefrontal cortex. We will focus on social cognition as a representative model for exploring and critically evaluating the relationship between olfactory cortices and higher-order cortical regions in rodent models. Although rodents do not recapitulate all dimensions of human social cognition, they have experimentally accessible neural circuits and well-established behavioral tests for social motivation, memory/recognition, and hierarchy, which can be extrapolated to other species including humans. In particular, the medial prefrontal cortex (mPFC) has been recognized as a key brain region in mediating social cognition in both rodents and humans. This review will highlight the underappreciated connectivity, both anatomical and functional, between the olfactory system and mPFC circuitry, which together provide a neural substrate for olfactory modulation of social cognition and social behaviors. We will provide future perspectives on the functional investigation of the olfactory-mPFC circuit in rodent models and discuss how to translate such animal research to human studies.
KW - Anterior olfactory nucleus
KW - Medial prefrontal cortex
KW - Neuropsychiatric diseases
KW - Olfactory function, olfactory cortex
KW - Social behaviors
KW - Social cognition
KW - Taenia tecta
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U2 - 10.1016/j.semcdb.2021.03.022
DO - 10.1016/j.semcdb.2021.03.022
M3 - Review article
C2 - 33975755
AN - SCOPUS:85105487124
SN - 1084-9521
VL - 129
SP - 31
EP - 39
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -