Older dopaminergic neurons do not recover from the effects of MPTP

G. A. Ricaurte; L. E. DeLanney; I. Irwin; J. W. Langston

doi:10.1016/0028-3908(87)90051-7

Older dopaminergic neurons do not recover from the effects of MPTP

G. A. Ricaurte, L. E. DeLanney, I. Irwin, J. W. Langston

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Recent studies have shown that dopaminergic neurons in young mature mice recover fully from toxic injury induced by MPTP. The aim of the present study was to assess whether or not older dopaminergic neurons were capable of similar recovery. We now report that older dopaminergic neurons do not recover from the effects of MPTP. This suggests that with age, neurons in the nigrostriatal system begin to lose their regenerative capacity. This phenomenon could underlie the process of neuronal degeneration known to occur in a number of age-related diseases, including Parkinson's disease.

Original language	English (US)
Pages (from-to)	97-99
Number of pages	3
Journal	Neuropharmacology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/0028-3908(87)90051-7
State	Published - Jan 1987
Externally published	Yes

Keywords

Aging
Dopamine
Parkinson's Disease
Recovery MPTP
Substantia Nigra

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/0028-3908(87)90051-7

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title = "Older dopaminergic neurons do not recover from the effects of MPTP",

abstract = "Recent studies have shown that dopaminergic neurons in young mature mice recover fully from toxic injury induced by MPTP. The aim of the present study was to assess whether or not older dopaminergic neurons were capable of similar recovery. We now report that older dopaminergic neurons do not recover from the effects of MPTP. This suggests that with age, neurons in the nigrostriatal system begin to lose their regenerative capacity. This phenomenon could underlie the process of neuronal degeneration known to occur in a number of age-related diseases, including Parkinson's disease.",

keywords = "Aging, Dopamine, Parkinson's Disease, Recovery MPTP, Substantia Nigra",

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note = "Funding Information: This work was supported in part by the United Parkinson Foundation, the Retirement Research Foundation, the Institute for Medical Research and NIEHS Grant ROl ES03697-02.",

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AU - Ricaurte, G. A.

AU - DeLanney, L. E.

AU - Irwin, I.

AU - Langston, J. W.

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N2 - Recent studies have shown that dopaminergic neurons in young mature mice recover fully from toxic injury induced by MPTP. The aim of the present study was to assess whether or not older dopaminergic neurons were capable of similar recovery. We now report that older dopaminergic neurons do not recover from the effects of MPTP. This suggests that with age, neurons in the nigrostriatal system begin to lose their regenerative capacity. This phenomenon could underlie the process of neuronal degeneration known to occur in a number of age-related diseases, including Parkinson's disease.

AB - Recent studies have shown that dopaminergic neurons in young mature mice recover fully from toxic injury induced by MPTP. The aim of the present study was to assess whether or not older dopaminergic neurons were capable of similar recovery. We now report that older dopaminergic neurons do not recover from the effects of MPTP. This suggests that with age, neurons in the nigrostriatal system begin to lose their regenerative capacity. This phenomenon could underlie the process of neuronal degeneration known to occur in a number of age-related diseases, including Parkinson's disease.

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KW - Parkinson's Disease

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KW - Substantia Nigra

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Older dopaminergic neurons do not recover from the effects of MPTP

Abstract

Keywords

ASJC Scopus subject areas

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