Oculomotor plasticity during vestibular compensation does not depend on cerebellar LTD

M. Faulstich, A. M. Van Alphen, C. Luo, S. Du Lac, C. I. De Zeeuw

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Vestibular paradigms are widely used for investigating mechanisms underlying cerebellar motor learning. These include adaptation of the vestibuloocular reflex (VOR) after visual-vestibular mismatch training and vestibular compensation after unilateral damage to the vestibular apparatus. To date, various studies have shown that VOR adaptation may be supported by long-term depression (LTD) at the parallel fiber to Purkinje cell synapse. Yet it is unknown to what extent vestibular compensation may depend on this cellular process. Here we investigated adaptive gain changes in the VOR and optokinetic reflex during vestibular compensation in transgenic mice in which LTD is specifically blocked in Purkinje cells via expression of a peptide inhibitor of protein kinase C (L7-PKCi mutants). The results demonstrate that neither the strength nor the time course of vestibular compensation are affected by the absence of LTD. In contrast, analysis of vestibular compensation in spontaneous mutants that lack a functional olivocerebellar circuit (lurchers) shows that this form of motor learning is severely impaired. We conclude that oculomotor plasticity during vestibular compensation depends critically on intact cerebellar circuitry but not on the occurrence of cerebellar LTD.

Original languageEnglish (US)
Pages (from-to)1187-1195
Number of pages9
JournalJournal of neurophysiology
Issue number3
StatePublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology


Dive into the research topics of 'Oculomotor plasticity during vestibular compensation does not depend on cerebellar LTD'. Together they form a unique fingerprint.

Cite this