TY - JOUR
T1 - Ocular Tissue Absorption of Minocycline in the Rabbit
AU - Tabbara, Khalid F.
AU - Ghosheh, Ribhi
AU - O'connor, G. Richard
PY - 1983
Y1 - 1983
N2 - After intramuscular (IM) administration of minocycline hydrochloride, concentrations of the drug that would be adequate for the control of sensitive organisms (>0.5 μg/g of tissue) were detectable in the cornea, iris, and retinochoroid 3, 6, and 12 hours after a single injection. The concentration of the drug in the aqueous humor was greater than in the vitreous humor. Following a single IM injection of 40 mg/kg, the drug level was found to be significantly higher in the iris and aqueous humor of pigmented rabbits than in the corresponding tissues of albino rabbits. The drug seems to concentrate in the pigmented layers of the ocular tissue.
AB - After intramuscular (IM) administration of minocycline hydrochloride, concentrations of the drug that would be adequate for the control of sensitive organisms (>0.5 μg/g of tissue) were detectable in the cornea, iris, and retinochoroid 3, 6, and 12 hours after a single injection. The concentration of the drug in the aqueous humor was greater than in the vitreous humor. Following a single IM injection of 40 mg/kg, the drug level was found to be significantly higher in the iris and aqueous humor of pigmented rabbits than in the corresponding tissues of albino rabbits. The drug seems to concentrate in the pigmented layers of the ocular tissue.
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U2 - 10.1001/archopht.1983.01040020428020
DO - 10.1001/archopht.1983.01040020428020
M3 - Article
C2 - 6615310
AN - SCOPUS:0020551058
SN - 0003-9950
VL - 101
SP - 1426
EP - 1428
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 9
ER -