TY - JOUR
T1 - Ocular determinants of peripapillary vessel density in healthy African Americans
T2 - The African American eye disease study
AU - African American Eye Disease Study Group
AU - Nelson, Andrew J.
AU - Chang, Ryuna
AU - Letran, Vivian
AU - Brian, Vu
AU - Burkemper, Bruce
AU - Chu, Zhongdi
AU - Fard, Ali
AU - Kashani, Amir
AU - Benjamin, Xu
AU - Wang, Ruikang
AU - Varma, Rohit
AU - Richter, Grace M.
N1 - Publisher Copyright:
© 2019 The Authors.
PY - 2019/8
Y1 - 2019/8
N2 - PURPOSE. The African American (AA) population has unique ocular anatomic characteristics and a disproportionately high incidence of glaucoma, which is associated with lower peripapillary vessel density (VD). This study aimed to identify ocular determinants of peripapillary VD in healthy AAs. METHODS. This was a cross-sectional, population-based study of 1029 AAs, ages 40 and older. Participants underwent examination to obtain axial length (AL), IOP, central corneal thickness (CCT), mean retinal nerve fiber layer (RNFL) thickness, visual field mean deviation (MD), and 6 ☓ 6-mm optical coherence tomography angiography scans of the optic nerve. Participants with glaucoma, vision-threatening diabetic retinopathy, or other relevant ocular disease were excluded. Prototype software was used to quantify VD. A multivariable regression model, controlling for age and signal strength, identified the ocular variables that predicted peripapillary VD. The contribution of each variable was assessed with the magnitude of standardized regression coefficients (SRC). RESULTS. Based on univariate regressions, AL, RNFL thickness, and MD had significant associations with peripapillary VD (all P < 0.001). In the final multivariate model, lower mean RNFL thickness (β = 0.0022, P < 0.001, SRC = 0.542) and longer AL (β = 0.0055, P < 0.001, SRC = 0.118) were associated with lower peripapillary VD, controlling for age and signal strength, with model R2 of 0.69. CONCLUSIONS. Thinner RNFL and longer AL were the most influential ocular determinants of lower peripapillary perfusion in healthy AA eyes. Additional research is needed to clarify whether longer AL increases risk of glaucoma by affecting capillary perfusion.
AB - PURPOSE. The African American (AA) population has unique ocular anatomic characteristics and a disproportionately high incidence of glaucoma, which is associated with lower peripapillary vessel density (VD). This study aimed to identify ocular determinants of peripapillary VD in healthy AAs. METHODS. This was a cross-sectional, population-based study of 1029 AAs, ages 40 and older. Participants underwent examination to obtain axial length (AL), IOP, central corneal thickness (CCT), mean retinal nerve fiber layer (RNFL) thickness, visual field mean deviation (MD), and 6 ☓ 6-mm optical coherence tomography angiography scans of the optic nerve. Participants with glaucoma, vision-threatening diabetic retinopathy, or other relevant ocular disease were excluded. Prototype software was used to quantify VD. A multivariable regression model, controlling for age and signal strength, identified the ocular variables that predicted peripapillary VD. The contribution of each variable was assessed with the magnitude of standardized regression coefficients (SRC). RESULTS. Based on univariate regressions, AL, RNFL thickness, and MD had significant associations with peripapillary VD (all P < 0.001). In the final multivariate model, lower mean RNFL thickness (β = 0.0022, P < 0.001, SRC = 0.542) and longer AL (β = 0.0055, P < 0.001, SRC = 0.118) were associated with lower peripapillary VD, controlling for age and signal strength, with model R2 of 0.69. CONCLUSIONS. Thinner RNFL and longer AL were the most influential ocular determinants of lower peripapillary perfusion in healthy AA eyes. Additional research is needed to clarify whether longer AL increases risk of glaucoma by affecting capillary perfusion.
KW - Epidemiology
KW - Glaucoma
KW - Optical coherence tomography angiography
KW - Retinal blood flow
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U2 - 10.1167/iovs.19-27035
DO - 10.1167/iovs.19-27035
M3 - Article
C2 - 31917454
AN - SCOPUS:85070682524
SN - 0146-0404
VL - 60
SP - 3368
EP - 3373
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 10
ER -