Ocular Copper Deposition Associated with Pulmonary Carcinoma, IgG Monoclonal Gammopathy and Hypercupremia: A Clinicopathologic Correlation

Neil F. Martin; Marilyn C. Kincaid; Walter J. Stark; Brent G. Petty; Jacques L. Surer; Lawrence W. Hirst; W. Richard Green

doi:10.1016/S0161-6420(83)34599-1

Ocular Copper Deposition Associated with Pulmonary Carcinoma, IgG Monoclonal Gammopathy and Hypercupremia: A Clinicopathologic Correlation

Neil F. Martin, Marilyn C. Kincaid, Walter J. Stark, Brent G. Petty, Jacques L. Surer, Lawrence W. Hirst, W. Richard Green

School of Medicine

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Hypercupremia with central deposition of copper in Descemet's membrane and lens capsule has been reported previously in lymphoproliferative disorders in two cases. A 60-year-old white man presented with visual acuity loss and was found to have an iridescent brown corneal and lenticular discoloration. Laboratory investigation revealed hypercupremia secondary to a poorly differentiated adenocarcinoma of the lung. Presence of copper in the eye was confirmed by specific atomic absorption spectra and histochemical stains of ocular tissue. This appears to be the first report of a carcinoma with associated hypercupremia presenting initially with ocular copper deposition.

Original language	English (US)
Pages (from-to)	110-116
Number of pages	7
Journal	Ophthalmology
Volume	90
Issue number	1
DOIs	https://doi.org/10.1016/S0161-6420(83)34599-1
State	Published - 1983

Keywords

Descemet's membrane
conjunctiva
copper deposition
hypercupremia
lens
pulmonary carcinoma

ASJC Scopus subject areas

Ophthalmology

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10.1016/S0161-6420(83)34599-1

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@article{5e8b9edb0456445eb279fb6064467d18,

title = "Ocular Copper Deposition Associated with Pulmonary Carcinoma, IgG Monoclonal Gammopathy and Hypercupremia: A Clinicopathologic Correlation",

abstract = "Hypercupremia with central deposition of copper in Descemet's membrane and lens capsule has been reported previously in lymphoproliferative disorders in two cases. A 60-year-old white man presented with visual acuity loss and was found to have an iridescent brown corneal and lenticular discoloration. Laboratory investigation revealed hypercupremia secondary to a poorly differentiated adenocarcinoma of the lung. Presence of copper in the eye was confirmed by specific atomic absorption spectra and histochemical stains of ocular tissue. This appears to be the first report of a carcinoma with associated hypercupremia presenting initially with ocular copper deposition.",

keywords = "Descemet's membrane, conjunctiva, copper deposition, hypercupremia, lens, pulmonary carcinoma",

author = "Martin, {Neil F.} and Kincaid, {Marilyn C.} and Stark, {Walter J.} and Petty, {Brent G.} and Surer, {Jacques L.} and Hirst, {Lawrence W.} and Green, {W. Richard}",

note = "Funding Information: Supported in part by Research Grant 01684 from the National Eye Institute' and grants from the Heed Foundation.t Presented at the Eighty-sixth Annual Meeting of the American Academy of Ophthalmology, Atlanta, Georgia, November 1-6,1981. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1983",

doi = "10.1016/S0161-6420(83)34599-1",

language = "English (US)",

volume = "90",

pages = "110--116",

journal = "Ophthalmology",

issn = "0161-6420",

publisher = "Elsevier Inc.",

number = "1",

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TY - JOUR

T1 - Ocular Copper Deposition Associated with Pulmonary Carcinoma, IgG Monoclonal Gammopathy and Hypercupremia

T2 - A Clinicopathologic Correlation

AU - Martin, Neil F.

AU - Kincaid, Marilyn C.

AU - Stark, Walter J.

AU - Petty, Brent G.

AU - Surer, Jacques L.

AU - Hirst, Lawrence W.

AU - Green, W. Richard

N1 - Funding Information: Supported in part by Research Grant 01684 from the National Eye Institute' and grants from the Heed Foundation.t Presented at the Eighty-sixth Annual Meeting of the American Academy of Ophthalmology, Atlanta, Georgia, November 1-6,1981. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1983

Y1 - 1983

N2 - Hypercupremia with central deposition of copper in Descemet's membrane and lens capsule has been reported previously in lymphoproliferative disorders in two cases. A 60-year-old white man presented with visual acuity loss and was found to have an iridescent brown corneal and lenticular discoloration. Laboratory investigation revealed hypercupremia secondary to a poorly differentiated adenocarcinoma of the lung. Presence of copper in the eye was confirmed by specific atomic absorption spectra and histochemical stains of ocular tissue. This appears to be the first report of a carcinoma with associated hypercupremia presenting initially with ocular copper deposition.

AB - Hypercupremia with central deposition of copper in Descemet's membrane and lens capsule has been reported previously in lymphoproliferative disorders in two cases. A 60-year-old white man presented with visual acuity loss and was found to have an iridescent brown corneal and lenticular discoloration. Laboratory investigation revealed hypercupremia secondary to a poorly differentiated adenocarcinoma of the lung. Presence of copper in the eye was confirmed by specific atomic absorption spectra and histochemical stains of ocular tissue. This appears to be the first report of a carcinoma with associated hypercupremia presenting initially with ocular copper deposition.

KW - Descemet's membrane

KW - conjunctiva

KW - copper deposition

KW - hypercupremia

KW - lens

KW - pulmonary carcinoma

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U2 - 10.1016/S0161-6420(83)34599-1

DO - 10.1016/S0161-6420(83)34599-1

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AN - SCOPUS:0020699594

SN - 0161-6420

VL - 90

SP - 110

EP - 116

JO - Ophthalmology

JF - Ophthalmology

IS - 1

ER -

Ocular Copper Deposition Associated with Pulmonary Carcinoma, IgG Monoclonal Gammopathy and Hypercupremia: A Clinicopathologic Correlation

Abstract

Keywords

ASJC Scopus subject areas

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