Obstructive sleep apnea: A cardiometabolic risk in obesity and the metabolic syndrome

Luciano F. Drager, Sônia M. Togeiro, Vsevolod Y. Polotsky, Geraldo Lorenzi-Filho

Research output: Contribution to journalReview articlepeer-review

347 Scopus citations


Obstructive sleep apnea (OSA) is an underdiagnosed condition characterized by recurrent episodes of obstruction of the upper airway leading to sleep fragmentation and intermittent hypoxia during sleep. Obesity predisposes to OSA, and the prevalence of OSA is increasing worldwide because of the ongoing epidemic of obesity. Recent evidence has shown that surrogate markers of cardiovascular risk, including sympathetic activation, systemic inflammation, and endothelial dysfunction, are significantly increased in obese patients with OSA versus those without OSA, suggesting that OSA is not simply an epiphenomenon of obesity. Moreover, findings from animal models and patients with OSA show that intermittent hypoxia exacerbates the metabolic dysfunction of obesity, augmenting insulin resistance and nonalcoholic fatty liver disease. In patients with the metabolic syndrome, the prevalence of moderate to severe OSA is very high (∼60%). In this population, OSA is independently associated with increased glucose and triglyceride levels as well as markers of inflammation, arterial stiffness, and atherosclerosis. A recent randomized, controlled, crossover study showed that effective treatment of OSA with continuous positive airway pressure for 3 months significantly reduced several components of the metabolic syndrome, including blood pressure, triglyceride levels, and visceral fat. Finally, several cohort studies have consistently shown that OSA is associated with increased cardiovascular mortality, independent of obesity. Taken together, these results support the concept that OSA exacerbates the cardiometabolic risk attributed to obesity and the metabolic syndrome. Recognition and treatment of OSA may decrease the cardiovascular risk in obese patients.

Original languageEnglish (US)
Pages (from-to)569-576
Number of pages8
JournalJournal of the American College of Cardiology
Issue number7
StatePublished - Aug 13 2013
Externally publishedYes


  • cardiovascular risk
  • metabolic syndrome
  • obesity
  • sleep apnea

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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