Observation of molecular inhibition and binding structures of amyloid peptides

Aihua Yang, Xia Li, Denghua Li, Min Zhang, Huiwen Du, Chao Li, Yuanyuan Guo, Xiaobo Mao, Mingdong Dong, Flemming Besenbacher, Yanlian Yang, Chen Wang, Chenxuan Wang

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Unveiling interactions between labeling molecules and amyloid fibrils is essential to develop new detection methods for studying amyloid structures under various conditions. This review endeavours to reflect the progress in studying interactions between molecular inhibitors and amyloid peptides using a series of experimental approaches, such as X-ray diffraction, nuclear magnetic resonance, scanning probe microscopy, and electron microscopy. The revealed binding mechanisms of anti-amyloid drugs and target proteins could benefit the rational design of drugs for prevention or treatment of amyloidal diseases.

Original languageEnglish (US)
Pages (from-to)1895-1909
Number of pages15
Issue number6
StatePublished - Mar 21 2012
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)


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