Obesity susceptibility loci and dietary intake in the Look AHEAD Trial

Jeanne M. McCaffery, George D. Papandonatos, Inga Peter, Gordon S. Huggins, Hollie A. Raynor, Linda M. Delahanty, Lawrence J Cheskin, Ashok Balasubramanyam, Lynne E. Wagenknecht, Rena R. Wing

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


Background: Genome-wide association studies (GWAS) have identified consistent associations with obesity. However, the mechanisms remain unclear. Objective: The objective was to determine the association between obesity susceptibility loci and dietary intake. Design: The association of GWAS-identified obesity risk alleles (FTO, MC4R, SH2B1, BDNF, INSIG2, TNNI3K, NISCH-STAB1, MTIF3, MAP2K5, QPCTL/GIPR, and PPARG) with dietary intake, measured through food-frequency questionnaires, was investigated in 2075 participants from the Look AHEAD (Action for Health in Diabetes) clinical trial. We adjusted for age, sex, population stratification, and study site. Results: Obesity risk alleles at FTO rs1421085 significantly predicted more eating episodes per day (P = 0.001)- an effect that persisted after adjustment for body weight (P = 0.004). Risk variants within BDNF were significantly associated with more servings from the dairy product and the meat, eggs, nuts, and beans food groups (P ≤ 0.004). The risk allele at SH2B1 rs4788099 was significantly associated with more servings of dairy products (P = 0.001), whereas the risk allele at TNNI3K rs1514176 was significantly associated with a lower percentage of energy from protein (P = 0.002). Conclusion: These findings suggest that obesity risk loci may affect the pattern and content of food consumption among overweight or obese individuals with type 2 diabetes. The Look AHEAD Genetic Ancillary Study was registered at clinicaltrials.gov as NCT01270763 and the Look AHEAD study as NCT00017953.

Original languageEnglish (US)
Pages (from-to)1477-1486
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Issue number6
StatePublished - Jun 1 2012

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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