Obesity Modifies the Effect of Fitness on Heart Rate Indices during Exercise Stress Testing in Asymptomatic Individuals

Ehimen C. Aneni; Ebenezer T. Oni; Chukwuemeka U. Osondu; Seth S. Martin; Michael J. Blaha; Emir Veledar; Arthur S. Agatston; Theodore Feldman; Jose A.M. Carvalho; Raquel D. Conceicąõ; Raul D. Santos; Khurram Nasir

doi:10.1159/000435907

Obesity Modifies the Effect of Fitness on Heart Rate Indices during Exercise Stress Testing in Asymptomatic Individuals

Ehimen C. Aneni, Ebenezer T. Oni, Chukwuemeka U. Osondu, Seth S. Martin, Michael J. Blaha, Emir Veledar, Arthur S. Agatston, Theodore Feldman, Jose A.M. Carvalho, Raquel D. Conceicąõ, Raul D. Santos, Khurram Nasir

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Objective: To assess the impact of aerobic fitness on exercise heart rate (HR) indices in an asymptomatic cohort across different body mass index (BMI) categories. Methods: We performed a cross-sectional analysis of 506 working-class Brazilian subjects, free of known clinical cardiovascular disease (e.g. ischemic heart disease and stroke) who underwent an exercise stress test. Results: There was a significant trend towards decreased HR at peak exercise, HR recovery and chronotropic index (CI) measures as BMI increased, but resting HR increased significantly across BMI categories. In multivariate analysis, the change in CI per unit change in metabolic equivalents of task was greater among the obese subjects than the normal-weight (2.7 vs.-0.07; p interaction = 0.029) and overweight (2.7 vs. 0.7; p interaction = 0.044) subjects. A similar pattern was seen with peak HR and HR recovery, although the formal tests of interaction did not achieve statistical significance. Conclusion: Our findings strongly suggest that fitness is associated with a favorable HR profile and is modified by BMI. Intervention programs should place emphasis on fitness and not only on weight loss.

Original language	English (US)
Pages (from-to)	242-248
Number of pages	7
Journal	Cardiology (Switzerland)
Volume	132
Issue number	4
DOIs	https://doi.org/10.1159/000435907
State	Published - Nov 12 2015

Keywords

Body mass index
Fitness
Heart rate
Metabolic equivalents
Obesity
Stress test

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Pharmacology (medical)

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10.1159/000435907

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Aneni, E. C., Oni, E. T., Osondu, C. U., Martin, S. S., Blaha, M. J., Veledar, E., Agatston, A. S., Feldman, T., Carvalho, J. A. M., Conceicąõ, R. D., Santos, R. D., & Nasir, K. (2015). Obesity Modifies the Effect of Fitness on Heart Rate Indices during Exercise Stress Testing in Asymptomatic Individuals. Cardiology (Switzerland), 132(4), 242-248. https://doi.org/10.1159/000435907

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abstract = "Objective: To assess the impact of aerobic fitness on exercise heart rate (HR) indices in an asymptomatic cohort across different body mass index (BMI) categories. Methods: We performed a cross-sectional analysis of 506 working-class Brazilian subjects, free of known clinical cardiovascular disease (e.g. ischemic heart disease and stroke) who underwent an exercise stress test. Results: There was a significant trend towards decreased HR at peak exercise, HR recovery and chronotropic index (CI) measures as BMI increased, but resting HR increased significantly across BMI categories. In multivariate analysis, the change in CI per unit change in metabolic equivalents of task was greater among the obese subjects than the normal-weight (2.7 vs.-0.07; p interaction = 0.029) and overweight (2.7 vs. 0.7; p interaction = 0.044) subjects. A similar pattern was seen with peak HR and HR recovery, although the formal tests of interaction did not achieve statistical significance. Conclusion: Our findings strongly suggest that fitness is associated with a favorable HR profile and is modified by BMI. Intervention programs should place emphasis on fitness and not only on weight loss.",

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author = "Aneni, {Ehimen C.} and Oni, {Ebenezer T.} and Osondu, {Chukwuemeka U.} and Martin, {Seth S.} and Blaha, {Michael J.} and Emir Veledar and Agatston, {Arthur S.} and Theodore Feldman and Carvalho, {Jose A.M.} and Conceic{\c a}{\~o}, {Raquel D.} and Santos, {Raul D.} and Khurram Nasir",

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AU - Oni, Ebenezer T.

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AU - Martin, Seth S.

AU - Blaha, Michael J.

AU - Veledar, Emir

AU - Agatston, Arthur S.

AU - Feldman, Theodore

AU - Carvalho, Jose A.M.

AU - Conceicąõ, Raquel D.

AU - Santos, Raul D.

AU - Nasir, Khurram

PY - 2015/11/12

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N2 - Objective: To assess the impact of aerobic fitness on exercise heart rate (HR) indices in an asymptomatic cohort across different body mass index (BMI) categories. Methods: We performed a cross-sectional analysis of 506 working-class Brazilian subjects, free of known clinical cardiovascular disease (e.g. ischemic heart disease and stroke) who underwent an exercise stress test. Results: There was a significant trend towards decreased HR at peak exercise, HR recovery and chronotropic index (CI) measures as BMI increased, but resting HR increased significantly across BMI categories. In multivariate analysis, the change in CI per unit change in metabolic equivalents of task was greater among the obese subjects than the normal-weight (2.7 vs.-0.07; p interaction = 0.029) and overweight (2.7 vs. 0.7; p interaction = 0.044) subjects. A similar pattern was seen with peak HR and HR recovery, although the formal tests of interaction did not achieve statistical significance. Conclusion: Our findings strongly suggest that fitness is associated with a favorable HR profile and is modified by BMI. Intervention programs should place emphasis on fitness and not only on weight loss.

AB - Objective: To assess the impact of aerobic fitness on exercise heart rate (HR) indices in an asymptomatic cohort across different body mass index (BMI) categories. Methods: We performed a cross-sectional analysis of 506 working-class Brazilian subjects, free of known clinical cardiovascular disease (e.g. ischemic heart disease and stroke) who underwent an exercise stress test. Results: There was a significant trend towards decreased HR at peak exercise, HR recovery and chronotropic index (CI) measures as BMI increased, but resting HR increased significantly across BMI categories. In multivariate analysis, the change in CI per unit change in metabolic equivalents of task was greater among the obese subjects than the normal-weight (2.7 vs.-0.07; p interaction = 0.029) and overweight (2.7 vs. 0.7; p interaction = 0.044) subjects. A similar pattern was seen with peak HR and HR recovery, although the formal tests of interaction did not achieve statistical significance. Conclusion: Our findings strongly suggest that fitness is associated with a favorable HR profile and is modified by BMI. Intervention programs should place emphasis on fitness and not only on weight loss.

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Obesity Modifies the Effect of Fitness on Heart Rate Indices during Exercise Stress Testing in Asymptomatic Individuals

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Keywords

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