TY - JOUR
T1 - Obesity and Overweight
T2 - Probing Causes, Consequences, and Novel Therapeutic Approaches Through the American Heart Association’s Strategically Focused Research Network
AU - Clark, Jeanne M.
AU - Garvey, W. Timothy
AU - Niswender, Kevin D.
AU - Schmidt, Ann Marie
AU - Ahima, Rexford S.
AU - Aleman, Jose O.
AU - Battarbee, Ashley N.
AU - Beckman, Joshua
AU - Bennett, Wendy L.
AU - Brown, Nancy J.
AU - Chandler-Laney, Paula
AU - Cox, Nancy
AU - Goldberg, Ira J.
AU - Habegger, Kirk M.
AU - Harper, Lorie M.
AU - Hasty, Alyssa H.
AU - Hidalgo, Bertha A.
AU - Kim, Sangwon F.
AU - Locher, Julie L.
AU - Luther, James M.
AU - Maruthur, Nisa M.
AU - Miller, Edgar R.
AU - Sevick, Mary Ann
AU - Wells, Quinn
N1 - Publisher Copyright:
© 2023 The Authors.
PY - 2023/2/21
Y1 - 2023/2/21
N2 - As the worldwide prevalence of overweight and obesity continues to rise, so too does the urgency to fully under-stand mediating mechanisms, to discover new targets for safe and effective therapeutic intervention, and to identify biomark-ers to track obesity and the success of weight loss interventions. In 2016, the American Heart Association sought applications for a Strategically Focused Research Network (SFRN) on Obesity. In 2017, 4 centers were named, including Johns Hopkins University School of Medicine, New York University Grossman School of Medicine, University of Alabama at Birmingham, and Vanderbilt University Medical Center. These 4 centers were convened to study mechanisms and therapeutic targets in obesity, to train a talented cadre of American Heart Association SFRN-designated fellows, and to initiate and sustain effective and enduring collaborations within the individual centers and throughout the SFRN networks. This review summarizes the central themes, major findings, successful training of highly motivated and productive fellows, and the innovative collaborations and studies forged through this SFRN on Obesity. Leveraging expertise in in vitro and cellular model assays, animal models, and humans, the work of these 4 centers has made a significant impact in the field of obesity, opening doors to important discov-eries, and the identification of a future generation of obesity-focused investigators and next-step clinical trials. The creation of the SFRN on Obesity for these 4 centers is but the beginning of innovative science and, importantly, the birth of new collaborations and research partnerships to propel the field forward.
AB - As the worldwide prevalence of overweight and obesity continues to rise, so too does the urgency to fully under-stand mediating mechanisms, to discover new targets for safe and effective therapeutic intervention, and to identify biomark-ers to track obesity and the success of weight loss interventions. In 2016, the American Heart Association sought applications for a Strategically Focused Research Network (SFRN) on Obesity. In 2017, 4 centers were named, including Johns Hopkins University School of Medicine, New York University Grossman School of Medicine, University of Alabama at Birmingham, and Vanderbilt University Medical Center. These 4 centers were convened to study mechanisms and therapeutic targets in obesity, to train a talented cadre of American Heart Association SFRN-designated fellows, and to initiate and sustain effective and enduring collaborations within the individual centers and throughout the SFRN networks. This review summarizes the central themes, major findings, successful training of highly motivated and productive fellows, and the innovative collaborations and studies forged through this SFRN on Obesity. Leveraging expertise in in vitro and cellular model assays, animal models, and humans, the work of these 4 centers has made a significant impact in the field of obesity, opening doors to important discov-eries, and the identification of a future generation of obesity-focused investigators and next-step clinical trials. The creation of the SFRN on Obesity for these 4 centers is but the beginning of innovative science and, importantly, the birth of new collaborations and research partnerships to propel the field forward.
KW - American Heart Association
KW - Strategically Focused Research Network
KW - obesity
KW - overweight
UR - http://www.scopus.com/inward/record.url?scp=85148479636&partnerID=8YFLogxK
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U2 - 10.1161/JAHA.122.027693
DO - 10.1161/JAHA.122.027693
M3 - Article
C2 - 36752232
AN - SCOPUS:85148479636
SN - 2047-9980
VL - 12
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 4
M1 - e8192
ER -