O-GlcNAc modification of nucleocytoplasmic proteins and diabetes

Yoshihiro Akimoto; Gerald Warren Hart; Hiroshi Hirano; Hayato Kawakami

doi:10.1007/s00795-004-0264-1

O-GlcNAc modification of nucleocytoplasmic proteins and diabetes

Yoshihiro Akimoto, Gerald Warren Hart, Hiroshi Hirano, Hayato Kawakami

School of Medicine

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Nuclear and cytosolic proteins are glycosylated on serine or threonine residues by O-linked β-N-acetylglucosamine (O-GlcNAc). O-GlcNAc modification is one of various posttranslational modifications and seems to be involved in the modulation of transcription and signal transduction. Accumulating data suggest a role for O-GlcNAc-modified proteins in diabetes, acting as a glucose sensor. It has been suggested that the hexosamine biosynthetic pathway is involved in the mechanism causing insulin resistance and diabetic complications. Excess glucose entering into the hexosamine biosynthetic pathway might cause elevated O-GlcNAc modification of various proteins. In this article, we review the current data regarding the relationship between O-GlcNAc modification and diabetes.

Original language	English (US)
Pages (from-to)	84-91
Number of pages	8
Journal	Medical Molecular Morphology
Volume	38
Issue number	2
DOIs	https://doi.org/10.1007/s00795-004-0264-1
State	Published - 2005

Keywords

Aorta
Cornea
Diabetes
Glycosyltransferase
Hexosamine biosynthetic pathway
O-GlcNAc
Pancreas

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology

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10.1007/s00795-004-0264-1

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abstract = "Nuclear and cytosolic proteins are glycosylated on serine or threonine residues by O-linked β-N-acetylglucosamine (O-GlcNAc). O-GlcNAc modification is one of various posttranslational modifications and seems to be involved in the modulation of transcription and signal transduction. Accumulating data suggest a role for O-GlcNAc-modified proteins in diabetes, acting as a glucose sensor. It has been suggested that the hexosamine biosynthetic pathway is involved in the mechanism causing insulin resistance and diabetic complications. Excess glucose entering into the hexosamine biosynthetic pathway might cause elevated O-GlcNAc modification of various proteins. In this article, we review the current data regarding the relationship between O-GlcNAc modification and diabetes.",

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T1 - O-GlcNAc modification of nucleocytoplasmic proteins and diabetes

AU - Akimoto, Yoshihiro

AU - Hart, Gerald Warren

AU - Hirano, Hiroshi

AU - Kawakami, Hayato

PY - 2005

Y1 - 2005

N2 - Nuclear and cytosolic proteins are glycosylated on serine or threonine residues by O-linked β-N-acetylglucosamine (O-GlcNAc). O-GlcNAc modification is one of various posttranslational modifications and seems to be involved in the modulation of transcription and signal transduction. Accumulating data suggest a role for O-GlcNAc-modified proteins in diabetes, acting as a glucose sensor. It has been suggested that the hexosamine biosynthetic pathway is involved in the mechanism causing insulin resistance and diabetic complications. Excess glucose entering into the hexosamine biosynthetic pathway might cause elevated O-GlcNAc modification of various proteins. In this article, we review the current data regarding the relationship between O-GlcNAc modification and diabetes.

AB - Nuclear and cytosolic proteins are glycosylated on serine or threonine residues by O-linked β-N-acetylglucosamine (O-GlcNAc). O-GlcNAc modification is one of various posttranslational modifications and seems to be involved in the modulation of transcription and signal transduction. Accumulating data suggest a role for O-GlcNAc-modified proteins in diabetes, acting as a glucose sensor. It has been suggested that the hexosamine biosynthetic pathway is involved in the mechanism causing insulin resistance and diabetic complications. Excess glucose entering into the hexosamine biosynthetic pathway might cause elevated O-GlcNAc modification of various proteins. In this article, we review the current data regarding the relationship between O-GlcNAc modification and diabetes.

KW - Aorta

KW - Cornea

KW - Diabetes

KW - Glycosyltransferase

KW - Hexosamine biosynthetic pathway

KW - O-GlcNAc

KW - Pancreas

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O-GlcNAc modification of nucleocytoplasmic proteins and diabetes

Abstract

Keywords

ASJC Scopus subject areas

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