TY - JOUR
T1 - Nutritional Status is Associated with Faster Cognitive Decline and Worse Functional Impairment in the Progression of Dementia
T2 - The Cache County Dementia Progression Study
AU - Sanders, Chelsea
AU - Behrens, Stephanie
AU - Schwartz, Sarah
AU - Wengreen, Heidi
AU - Corcoran, Chris D.
AU - Lyketsos, Constantine G.
AU - Tschanz, Joann T.
N1 - Funding Information:
ACKNOWLEDGMENTS: This study is supported by NIH grants: R01A G21136, R01AG11380, and the Johns Hopkins Alzheimer's Disease Research Center P50AG005146.
Publisher Copyright:
© 2016 IOS Press and the authors. All rights reserved.
PY - 2016/4/26
Y1 - 2016/4/26
N2 - Nutritional status may be a modifiable factor in the progression of dementia. We examined the association of nutritional status and rate of cognitive and functional decline in a U.S. population-based sample. Study design was an observational longitudinal study with annual follow-ups up to 6 years of 292 persons with dementia (72 Alzheimer's disease, 56 female) in Cache County, UT using the Mini-Mental State Exam (MMSE), Clinical Dementia Rating Sum of Boxes (CDR-sb), and modified Mini Nutritional Assessment (mMNA). mMNA scores declined by approximately 0.50 points/year, suggesting increasing risk for malnutrition. Lower mMNA score predicted faster rate of decline on the MMSE at earlier follow-up times, but slower decline at later follow-up times, whereas higher mMNA scores had the opposite pattern (mMNA by time β= 0.22, p = 0.017; mMNA by time2 β= -0.04, p = 0.04). Lower mMNA score was associated with greater impairment on the CDR-sb over the course of dementia (β= 0.35, p < 0.001). Assessment of malnutrition may be useful in predicting rates of progression in dementia and may provide a target for clinical intervention.
AB - Nutritional status may be a modifiable factor in the progression of dementia. We examined the association of nutritional status and rate of cognitive and functional decline in a U.S. population-based sample. Study design was an observational longitudinal study with annual follow-ups up to 6 years of 292 persons with dementia (72 Alzheimer's disease, 56 female) in Cache County, UT using the Mini-Mental State Exam (MMSE), Clinical Dementia Rating Sum of Boxes (CDR-sb), and modified Mini Nutritional Assessment (mMNA). mMNA scores declined by approximately 0.50 points/year, suggesting increasing risk for malnutrition. Lower mMNA score predicted faster rate of decline on the MMSE at earlier follow-up times, but slower decline at later follow-up times, whereas higher mMNA scores had the opposite pattern (mMNA by time β= 0.22, p = 0.017; mMNA by time2 β= -0.04, p = 0.04). Lower mMNA score was associated with greater impairment on the CDR-sb over the course of dementia (β= 0.35, p < 0.001). Assessment of malnutrition may be useful in predicting rates of progression in dementia and may provide a target for clinical intervention.
KW - Cognitive symptoms
KW - dementia
KW - disease progression
KW - malnutrition
KW - nutrition assessment
UR - http://www.scopus.com/inward/record.url?scp=84973103312&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973103312&partnerID=8YFLogxK
U2 - 10.3233/JAD-150528
DO - 10.3233/JAD-150528
M3 - Article
C2 - 26967207
AN - SCOPUS:84973103312
SN - 1387-2877
VL - 52
SP - 33
EP - 42
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 1
ER -