Abstract
Purpose Many diet based studies on metabolic syndrome lack an in-depth study of feed nutrient profile post preparation. We analyzed the nutritional profile of formulated High Fat Simple Carbohydrate (HFSC) feed and studied its effect on target organs. Methods Control feed and HFSC feed were analyzed for macro and micronutrient profile and fed to one month male C57BL/6J mice for 5 months during which feed intake, energy intake and feed efficiency was monitored. The effects of feeds were preliminarily studied on kidney, liver, adrenal gland and pancreas by histological staining. Results The HFSC feed had significantly lower carbohydrate, moisture, crude fiber, ash content, mineral, vitamin content, higher ω-6/ω-3 fatty acid ratio as compared to control feed. The HFSC fed mice had higher food intake; energy intake; feed efficiency; lymphocyte infiltration in the liver; hypertrophy of the kidney, adrenal medulla and degenerated islets of pancreas as compared to the control mice after 5 months of feeding. Conclusion Food with a higher ω-6/ω-3 fatty acid ratio and simple carbohydrate leads to deterioration of structural integrity of vital organs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 41-49 |
| Number of pages | 9 |
| Journal | Journal of Nutrition and Intermediary Metabolism |
| Volume | 3 |
| DOIs | |
| State | Published - Mar 1 2016 |
| Externally published | Yes |
Keywords
- C57BL/6J
- Fatty acid profile
- Fatty liver
- High fat simple carbohydrate feed
- Islet hypertrophy
- ω-6/ω-3
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Food Science
- Nutrition and Dietetics
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