Nutrient regulation of signaling, transcription, and cell physiology by O- GlcNAcylation

Stéphan Hardivillé; Gerald W. Hart

doi:10.1016/j.cmet.2014.07.014

Nutrient regulation of signaling, transcription, and cell physiology by O- GlcNAcylation

Stéphan Hardivillé
, Gerald W. Hart

Research output: Contribution to journal › Review article › peer-review

206 Scopus citations

Abstract

The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many cellular processes, including transcription and signaling. Dysregulated O-GlcNAcylation and its interplay with phosphorylation contribute to the etiology of diabetes, cancer, and neurodegeneration. Herein, we review recent findings about O-GlcNAc's regulation of cell physiology.

Original language	English (US)
Pages (from-to)	208-213
Number of pages	6
Journal	Cell Metabolism
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2014.07.014
State	Published - Aug 5 2014
Externally published	Yes

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2014.07.014

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title = "Nutrient regulation of signaling, transcription, and cell physiology by O- GlcNAcylation",

abstract = "The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many cellular processes, including transcription and signaling. Dysregulated O-GlcNAcylation and its interplay with phosphorylation contribute to the etiology of diabetes, cancer, and neurodegeneration. Herein, we review recent findings about O-GlcNAc's regulation of cell physiology.",

author = "St{\'e}phan Hardivill{\'e} and Hart, \{Gerald W.\}",

note = "Funding Information: The authors are supported by NIH R01CA42486, R01DK61671, P01HL107153, and N01-HV-00240. G.W.H. receives a share of royalties received by Johns Hopkins University on sales of the CTD 110.6 antibody, which are managed by JHU. We would like to thank Dr. S.B. Peterson and Dr. P.S. Banerjee for critical reading of the manuscript. We apologize to our colleagues whose original work could not be cited due to space constraints.",

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N2 - The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many cellular processes, including transcription and signaling. Dysregulated O-GlcNAcylation and its interplay with phosphorylation contribute to the etiology of diabetes, cancer, and neurodegeneration. Herein, we review recent findings about O-GlcNAc's regulation of cell physiology.

AB - The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many cellular processes, including transcription and signaling. Dysregulated O-GlcNAcylation and its interplay with phosphorylation contribute to the etiology of diabetes, cancer, and neurodegeneration. Herein, we review recent findings about O-GlcNAc's regulation of cell physiology.

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Nutrient regulation of signaling, transcription, and cell physiology by O- GlcNAcylation

Abstract

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