Nutrient regulation of cancer cells by o-glcnacylation

Xin Liu, Gerald Warren Hart

Research output: Chapter in Book/Report/Conference proceedingChapter


O-linked β-N-acetylglucosamine (O-GlcNAc) is a ubiquitous and dynamic posttranslational modification that occurs on serine/threonine residues of nuclear and cytoplasmic proteins. This modification is regulated by O-GlcNAc transferase (OGT), which attaches O-GlcNAc to proteins and O-GlcNAcase (OGA), which removes O-GlcNAc. O-GlcNAc serves as a nutrient sensor to regulate virtually all cellular processes, as well as playing roles in various diseases, including Alzheimer’s disease, diabetes, and cancer. In this chapter, we present an overview of O-GlcNAcylation in different kinds of cancer.

Original languageEnglish (US)
Title of host publicationGlycosignals in Cancer: Mechanisms of Malignant Phenotypes
PublisherSpringer Japan
Number of pages14
ISBN (Print)9784431559399, 9784431559375
StatePublished - Jan 1 2016


  • Cancer
  • Nutrients
  • O-glcnac
  • O-glcnac transferase
  • O-glcnacase
  • Oga
  • Ogt

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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