Nutrient regulation of cancer cells by o-glcnacylation

Xin Liu; Gerald Warren Hart

doi:10.1007/978-4-431-55939-9_6

Nutrient regulation of cancer cells by o-glcnacylation

Xin Liu, Gerald Warren Hart

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

O-linked β-N-acetylglucosamine (O-GlcNAc) is a ubiquitous and dynamic posttranslational modification that occurs on serine/threonine residues of nuclear and cytoplasmic proteins. This modification is regulated by O-GlcNAc transferase (OGT), which attaches O-GlcNAc to proteins and O-GlcNAcase (OGA), which removes O-GlcNAc. O-GlcNAc serves as a nutrient sensor to regulate virtually all cellular processes, as well as playing roles in various diseases, including Alzheimer’s disease, diabetes, and cancer. In this chapter, we present an overview of O-GlcNAcylation in different kinds of cancer.

Original language	English (US)
Title of host publication	Glycosignals in Cancer: Mechanisms of Malignant Phenotypes
Publisher	Springer Japan
Pages	95-108
Number of pages	14
ISBN (Print)	9784431559399, 9784431559375
DOIs	https://doi.org/10.1007/978-4-431-55939-9_6
State	Published - Jan 1 2016

Keywords

Cancer
Nutrients
O-glcnac
O-glcnac transferase
O-glcnacase
Oga
Ogt

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Medicine

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10.1007/978-4-431-55939-9_6

Cite this

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abstract = "O-linked β-N-acetylglucosamine (O-GlcNAc) is a ubiquitous and dynamic posttranslational modification that occurs on serine/threonine residues of nuclear and cytoplasmic proteins. This modification is regulated by O-GlcNAc transferase (OGT), which attaches O-GlcNAc to proteins and O-GlcNAcase (OGA), which removes O-GlcNAc. O-GlcNAc serves as a nutrient sensor to regulate virtually all cellular processes, as well as playing roles in various diseases, including Alzheimer{\textquoteright}s disease, diabetes, and cancer. In this chapter, we present an overview of O-GlcNAcylation in different kinds of cancer.",

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AB - O-linked β-N-acetylglucosamine (O-GlcNAc) is a ubiquitous and dynamic posttranslational modification that occurs on serine/threonine residues of nuclear and cytoplasmic proteins. This modification is regulated by O-GlcNAc transferase (OGT), which attaches O-GlcNAc to proteins and O-GlcNAcase (OGA), which removes O-GlcNAc. O-GlcNAc serves as a nutrient sensor to regulate virtually all cellular processes, as well as playing roles in various diseases, including Alzheimer’s disease, diabetes, and cancer. In this chapter, we present an overview of O-GlcNAcylation in different kinds of cancer.

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KW - O-glcnacase

KW - Oga

KW - Ogt

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Nutrient regulation of cancer cells by o-glcnacylation

Abstract

Keywords

ASJC Scopus subject areas

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