TY - JOUR
T1 - Nucleotide sequence databases
T2 - A gold mine for biologists
AU - Pandey, Akhilesh
AU - Lewitter, Fran
PY - 1999/7/1
Y1 - 1999/7/1
N2 - The rapid expansion of nucleotide sequence data available in public databases is revolutionizing biomedical research. These databases have a variety of uses, including the discovery of novel genes, identification of homologous genes, analysis of alternative splicing, chromosomal localization of genes, and detection of polymorphisms. Data sets such as the human transcript map will undoubtedly accelerate identification of candidate genes in positional-cloning approaches. Careful in silico analysis can significantly reduce the amount of lab work required. Approximately half of all human genes are represented in these databases; therefore, one need not wait for the entire human genome to be sequenced before performing genome-wide studies. Copyright (C) 1999 Elsevier Science Ltd.
AB - The rapid expansion of nucleotide sequence data available in public databases is revolutionizing biomedical research. These databases have a variety of uses, including the discovery of novel genes, identification of homologous genes, analysis of alternative splicing, chromosomal localization of genes, and detection of polymorphisms. Data sets such as the human transcript map will undoubtedly accelerate identification of candidate genes in positional-cloning approaches. Careful in silico analysis can significantly reduce the amount of lab work required. Approximately half of all human genes are represented in these databases; therefore, one need not wait for the entire human genome to be sequenced before performing genome-wide studies. Copyright (C) 1999 Elsevier Science Ltd.
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U2 - 10.1016/S0968-0004(99)01400-0
DO - 10.1016/S0968-0004(99)01400-0
M3 - Article
C2 - 10390617
AN - SCOPUS:0033167908
SN - 0968-0004
VL - 24
SP - 276
EP - 280
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 7
ER -