Nucleoside excretion in breast cancer: Comparison with other biochemical tumour-index-substances

R. C. Coombes, T. J. Powles, C. W. Gehrke, T. P. Waalkes, A. M. Neville

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The authors have measured four urinary nucleosides (dimethylguanosine, 1-methylinosine, psueouridine and β-aminoisobutyric acid) in patients with benign breast disease and patients with early and advanced breast cancer in order to assess their value as tumour-index-substances. They compared the results with other biochemical indices of breast cancer and sought any correlations between these indices. The results indicate that few abnormalities occurred in patients without overt metastases and these did not predict early relapse. In those with metastatic disease, dimethylguanosine excretion was most frequently elevated. Correlations were observed between some of the nucleosides and lysozyme and α 1-antitrypsin.

Original languageEnglish (US)
Pages (from-to)11-14
Number of pages4
JournalInvestigative and Cell Pathology
Issue number1
StatePublished - Dec 1 1979

ASJC Scopus subject areas

  • Medicine(all)


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