Nucleoside excretion in breast cancer: Comparison with other biochemical tumour-index-substances

R. C. Coombes; T. J. Powles; C. W. Gehrke; T. P. Waalkes; A. M. Neville

Nucleoside excretion in breast cancer: Comparison with other biochemical tumour-index-substances

R. C. Coombes, T. J. Powles, C. W. Gehrke, T. P. Waalkes, A. M. Neville

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The authors have measured four urinary nucleosides (dimethylguanosine, 1-methylinosine, psueouridine and β-aminoisobutyric acid) in patients with benign breast disease and patients with early and advanced breast cancer in order to assess their value as tumour-index-substances. They compared the results with other biochemical indices of breast cancer and sought any correlations between these indices. The results indicate that few abnormalities occurred in patients without overt metastases and these did not predict early relapse. In those with metastatic disease, dimethylguanosine excretion was most frequently elevated. Correlations were observed between some of the nucleosides and lysozyme and α ₁-antitrypsin.

Original language	English (US)
Pages (from-to)	11-14
Number of pages	4
Journal	Investigative and Cell Pathology
Volume	2
Issue number	1
State	Published - Dec 1 1979

ASJC Scopus subject areas

Medicine(all)

Cite this

@article{9b1b0e19994e47bdb1dc7058170b82cb,

title = "Nucleoside excretion in breast cancer: Comparison with other biochemical tumour-index-substances",

abstract = "The authors have measured four urinary nucleosides (dimethylguanosine, 1-methylinosine, psueouridine and β-aminoisobutyric acid) in patients with benign breast disease and patients with early and advanced breast cancer in order to assess their value as tumour-index-substances. They compared the results with other biochemical indices of breast cancer and sought any correlations between these indices. The results indicate that few abnormalities occurred in patients without overt metastases and these did not predict early relapse. In those with metastatic disease, dimethylguanosine excretion was most frequently elevated. Correlations were observed between some of the nucleosides and lysozyme and α 1-antitrypsin.",

author = "Coombes, {R. C.} and Powles, {T. J.} and Gehrke, {C. W.} and Waalkes, {T. P.} and Neville, {A. M.}",

year = "1979",

month = dec,

day = "1",

language = "English (US)",

volume = "2",

pages = "11--14",

journal = "Investigative and Cell Pathology",

issn = "0022-3417",

publisher = "John Wiley and Sons Ltd",

number = "1",

}

TY - JOUR

T1 - Nucleoside excretion in breast cancer

T2 - Comparison with other biochemical tumour-index-substances

AU - Coombes, R. C.

AU - Powles, T. J.

AU - Gehrke, C. W.

AU - Waalkes, T. P.

AU - Neville, A. M.

PY - 1979/12/1

Y1 - 1979/12/1

N2 - The authors have measured four urinary nucleosides (dimethylguanosine, 1-methylinosine, psueouridine and β-aminoisobutyric acid) in patients with benign breast disease and patients with early and advanced breast cancer in order to assess their value as tumour-index-substances. They compared the results with other biochemical indices of breast cancer and sought any correlations between these indices. The results indicate that few abnormalities occurred in patients without overt metastases and these did not predict early relapse. In those with metastatic disease, dimethylguanosine excretion was most frequently elevated. Correlations were observed between some of the nucleosides and lysozyme and α 1-antitrypsin.

AB - The authors have measured four urinary nucleosides (dimethylguanosine, 1-methylinosine, psueouridine and β-aminoisobutyric acid) in patients with benign breast disease and patients with early and advanced breast cancer in order to assess their value as tumour-index-substances. They compared the results with other biochemical indices of breast cancer and sought any correlations between these indices. The results indicate that few abnormalities occurred in patients without overt metastases and these did not predict early relapse. In those with metastatic disease, dimethylguanosine excretion was most frequently elevated. Correlations were observed between some of the nucleosides and lysozyme and α 1-antitrypsin.

UR - http://www.scopus.com/inward/record.url?scp=0018764460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018764460&partnerID=8YFLogxK

M3 - Article

C2 - 511604

AN - SCOPUS:0018764460

SN - 0022-3417

VL - 2

SP - 11

EP - 14

JO - Investigative and Cell Pathology

JF - Investigative and Cell Pathology

IS - 1

ER -

Nucleoside excretion in breast cancer: Comparison with other biochemical tumour-index-substances

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this