Nuclear roundness factor: A quantitative approach to grading in prostatic carcinoma, reliability of needle biopsy tissue, and the effect of tumor stage on usefulness

Terry D. Clark; Frederic B. Askin; Charles R. Bagnell

doi:10.1002/pros.2990100303

Nuclear roundness factor: A quantitative approach to grading in prostatic carcinoma, reliability of needle biopsy tissue, and the effect of tumor stage on usefulness

Terry D. Clark, Frederic B. Askin, Charles R. Bagnell

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Morphometric analysis and histologic grading were performed on case material from 26 patients. Relative nuclear roundness factor (RNRF) was calculated and correlated with clinical course in 14 patients undergoing prostatectomy for stage A or B prostatic carcinoma. The only patients with progression of disease were two with RNRF of 1.10. RNRF in cases without progression ranged from 0.98 to 1.07. Histologic grading by the methods of Gleason or the M.D. Anderson system failed to discriminate between the progressing and nonpro‐gressing groups. However, when RNRF was measured in tumors initially diagnosed as stage C or D, four of eight were below 1.10, within the range of the nonprogressing low‐stage cases. Thus, the usefulness of morphometry and RNRF may be limited to low‐stage disease. It was additionally found that RNRF could not be reliably measured in needle biopsy specimens.

Original language	English (US)
Pages (from-to)	199-206
Number of pages	8
Journal	The Prostate
Volume	10
Issue number	3
DOIs	https://doi.org/10.1002/pros.2990100303
State	Published - 1987
Externally published	Yes

Keywords

automated cytology
image analysis
morphometry
prognosis

ASJC Scopus subject areas

Oncology
Urology

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10.1002/pros.2990100303

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title = "Nuclear roundness factor: A quantitative approach to grading in prostatic carcinoma, reliability of needle biopsy tissue, and the effect of tumor stage on usefulness",

abstract = "Morphometric analysis and histologic grading were performed on case material from 26 patients. Relative nuclear roundness factor (RNRF) was calculated and correlated with clinical course in 14 patients undergoing prostatectomy for stage A or B prostatic carcinoma. The only patients with progression of disease were two with RNRF of 1.10. RNRF in cases without progression ranged from 0.98 to 1.07. Histologic grading by the methods of Gleason or the M.D. Anderson system failed to discriminate between the progressing and nonpro‐gressing groups. However, when RNRF was measured in tumors initially diagnosed as stage C or D, four of eight were below 1.10, within the range of the nonprogressing low‐stage cases. Thus, the usefulness of morphometry and RNRF may be limited to low‐stage disease. It was additionally found that RNRF could not be reliably measured in needle biopsy specimens.",

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T2 - A quantitative approach to grading in prostatic carcinoma, reliability of needle biopsy tissue, and the effect of tumor stage on usefulness

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AU - Askin, Frederic B.

AU - Bagnell, Charles R.

PY - 1987

Y1 - 1987

N2 - Morphometric analysis and histologic grading were performed on case material from 26 patients. Relative nuclear roundness factor (RNRF) was calculated and correlated with clinical course in 14 patients undergoing prostatectomy for stage A or B prostatic carcinoma. The only patients with progression of disease were two with RNRF of 1.10. RNRF in cases without progression ranged from 0.98 to 1.07. Histologic grading by the methods of Gleason or the M.D. Anderson system failed to discriminate between the progressing and nonpro‐gressing groups. However, when RNRF was measured in tumors initially diagnosed as stage C or D, four of eight were below 1.10, within the range of the nonprogressing low‐stage cases. Thus, the usefulness of morphometry and RNRF may be limited to low‐stage disease. It was additionally found that RNRF could not be reliably measured in needle biopsy specimens.

AB - Morphometric analysis and histologic grading were performed on case material from 26 patients. Relative nuclear roundness factor (RNRF) was calculated and correlated with clinical course in 14 patients undergoing prostatectomy for stage A or B prostatic carcinoma. The only patients with progression of disease were two with RNRF of 1.10. RNRF in cases without progression ranged from 0.98 to 1.07. Histologic grading by the methods of Gleason or the M.D. Anderson system failed to discriminate between the progressing and nonpro‐gressing groups. However, when RNRF was measured in tumors initially diagnosed as stage C or D, four of eight were below 1.10, within the range of the nonprogressing low‐stage cases. Thus, the usefulness of morphometry and RNRF may be limited to low‐stage disease. It was additionally found that RNRF could not be reliably measured in needle biopsy specimens.

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KW - image analysis

KW - morphometry

KW - prognosis

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Nuclear roundness factor: A quantitative approach to grading in prostatic carcinoma, reliability of needle biopsy tissue, and the effect of tumor stage on usefulness

Abstract

Keywords

ASJC Scopus subject areas

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