Nuclear Pore Dysfunction in Neurodegeneration

Olivia Spead, Benjamin L. Zaepfel, Jeffrey D. Rothstein

Research output: Contribution to journalReview articlepeer-review


The nuclear pore complex (NPC) is a large multimeric structure that is interspersed throughout the membrane of the nucleus and consists of at least 33 protein components. Individual components cooperate within the nuclear pore to facilitate selective passage of materials between the nucleus and cytoplasm while simultaneously performing pore-independent roles throughout the cell. NPC dysfunction is a hallmark of neurodegenerative disorders including Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS). NPC components can become mislocalized or altered in expression in neurodegeneration. These alterations in NPC structure are often detrimental to the neuronal function and ultimately lead to neuronal loss. This review highlights the importance of nucleocytoplasmic transport and NPC integrity and how dysfunction of such may contribute to neurodegeneration.

Original languageEnglish (US)
Pages (from-to)1050-1060
Number of pages11
Issue number4
StatePublished - Jul 2022


  • ALS
  • Alzheimer’s disease
  • Huntington’s disease
  • Neurodegeneration
  • Nuclear pore complex
  • Nucleocytoplasmic transport

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)


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