Nuclear localization of histamine in neonatal rat brain

Anne B. Young; Candace D. Pert; David G. Brown; Kenneth M. Taylor; Solomon H. Snyder

doi:10.1126/science.173.3993.247

Nuclear localization of histamine in neonatal rat brain

Anne B. Young, Candace D. Pert, David G. Brown, Kenneth M. Taylor, Solomon H. Snyder

School of Medicine

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Abstract

The concentration of histamine in the brains of neonatal rats is considerably higher than that in adults. Subcellular fractionation studies revealed that about 90 percent of the histamine content of neonatal rat brain is confined to the crude nuclear fraction obtained by differential fractionation. Purified nuclei prepared from these fractions retained 90 percent of their histamine content. The nuclear localization of histamine in the brains of neonatal rats suggests a function for histamine in modulating the growth processes of the neonatal brain.

Original language	English (US)
Pages (from-to)	247-249
Number of pages	3
Journal	Science
Volume	173
Issue number	3993
DOIs	https://doi.org/10.1126/science.173.3993.247
State	Published - 1971

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title = "Nuclear localization of histamine in neonatal rat brain",

abstract = "The concentration of histamine in the brains of neonatal rats is considerably higher than that in adults. Subcellular fractionation studies revealed that about 90 percent of the histamine content of neonatal rat brain is confined to the crude nuclear fraction obtained by differential fractionation. Purified nuclei prepared from these fractions retained 90 percent of their histamine content. The nuclear localization of histamine in the brains of neonatal rats suggests a function for histamine in modulating the growth processes of the neonatal brain.",

author = "Young, {Anne B.} and Pert, {Candace D.} and Brown, {David G.} and Taylor, {Kenneth M.} and Snyder, {Solomon H.}",

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AU - Pert, Candace D.

AU - Brown, David G.

AU - Taylor, Kenneth M.

AU - Snyder, Solomon H.

PY - 1971

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N2 - The concentration of histamine in the brains of neonatal rats is considerably higher than that in adults. Subcellular fractionation studies revealed that about 90 percent of the histamine content of neonatal rat brain is confined to the crude nuclear fraction obtained by differential fractionation. Purified nuclei prepared from these fractions retained 90 percent of their histamine content. The nuclear localization of histamine in the brains of neonatal rats suggests a function for histamine in modulating the growth processes of the neonatal brain.

AB - The concentration of histamine in the brains of neonatal rats is considerably higher than that in adults. Subcellular fractionation studies revealed that about 90 percent of the histamine content of neonatal rat brain is confined to the crude nuclear fraction obtained by differential fractionation. Purified nuclei prepared from these fractions retained 90 percent of their histamine content. The nuclear localization of histamine in the brains of neonatal rats suggests a function for histamine in modulating the growth processes of the neonatal brain.

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Nuclear localization of histamine in neonatal rat brain

Abstract

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