Nuclear envelope in nuclear positioning and cell migration

David Razafsky, Denis Wirtz, Didier Hodzic

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Scopus citations


Hauling and anchoring the nucleus within immobile or motile cells, tissues, and/or syncytia represents a major challenge. In the past 15 years, Linkers of the Nucleoskeleton to the Cytoskeleton (LINC complexes) have emerged as evolutionary-conserved molecular devices that span the nuclear envelope and provide interacting interfaces for cytoskeletal networks and molecular motors to the nuclear envelope. Here, we review the molecular composition of LINC complexes and focus on how their genetic alteration in vivo has provided a wealth of information related to the relevance of nuclear positioning during tissue development and homeostasis with a special emphasis on the central nervous system. As it may be relevant for metastasis in a range of cancers, the involvement of LINC complexes in migration of nonneuronal cells via its interaction with the perinuclear actin cap will also be developed.

Original languageEnglish (US)
Title of host publicationCancer Biology and the Nuclear Envelope
Subtitle of host publicationRecent Advances May Elucidate Past Paradoxes
PublisherSpringer New York LLC
Number of pages20
ISBN (Print)9781489980311
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


  • Actin cap
  • Cell motility
  • Interkinetic nuclear migration
  • KASH domain
  • LINC complexes
  • Nesprin
  • Neuronal migration
  • Nuclear anchorage
  • Nuclear lamina
  • Retina
  • SUN domain
  • Skeletal muscle
  • Sun protein

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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