(N‐[11C]‐Methyl)doxepin: Synthesis of a radiotracer for studying the histamine H‐1 receptor

Hayden T. Ravert, Robert F. Dannals, Alan A. Wilson, Henry N. Wagner

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Doxepin (3‐dibenz [b,e] oxepin ‐ 11(6H) ‐ ylidene ‐ N,N ‐ dimethyl ‐ 1 ‐ propanamine), a potent H1 histamine antagonist, was labeled with 11C‐iodomethane by N‐alkylation of normethyldoxepin. The synthesis, purification, and formulation were performed in approximately 20 minutes with an average specific activity of 1630 mCi/μmol (EOS).

Original languageEnglish (US)
Pages (from-to)403-407
Number of pages5
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number5
StatePublished - May 1992


  • Doxepin
  • carbon‐11
  • histamine
  • positron emission tomography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry


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