Novel roles for the NF-κB signaling pathway in regulating neuronal function

Matt C. Boersma, Mollie K. Meffert

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Two new reports offer exciting evidence of novel roles for components of the nuclear factor κB (NF-κB) pathway in the nervous system. Transcriptional activation by NF-κB and chromatin remodeling by inhibitor of κB (IκB) kinase complex (IKK) have been linked to recall and reconsolidation of conditioned fear memories in the mammalian central nervous system. In the Drosophila neuromuscular junction, a member of the NF-κB family has been reported to regulate glutamate receptor clustering. Both reports could have important implications for the function of the NF-κB signaling pathway in neuronal plasticity.

Original languageEnglish (US)
Article number16pe7
JournalScience signaling
Issue number6
StatePublished - Feb 12 2008

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Novel roles for the NF-κB signaling pathway in regulating neuronal function'. Together they form a unique fingerprint.

Cite this