@inproceedings{384be02291df4041829a6361aa36a9fe,
title = "Novel polyketides from genetic engineering (... and lessons we have learned from making them)",
abstract = "Knowledge of the domain organization of type I modular polyketide synthases (PKS) usually allows accurate prediction of the structure of the corresponding polyketide. Genetic engineering of such PKSs can be employed to produce novel compounds of predicted structure. Genetic engineering of the epothilone PKS has given unexpected results that have revealed subtleties of the biosynthesis not previously understood. In one instance, an unprecedented mechanism was uncovered.",
author = "Leonard Katz and Jonathan Kennedy and Mutka, {Sarah C.} and Carney, {John R.} and MacMillan, {Karen S.} and Sumati Murli",
year = "2007",
doi = "10.1021/bk-2007-0955.ch014",
language = "English (US)",
isbn = "0841239789",
series = "ACS Symposium Series",
publisher = "American Chemical Society",
pages = "200--216",
booktitle = "Polyketides Biosynthesis, Biological Activity, and Genetic Engineering",
}