@article{e41071300efe465984dc000be73835a9,
title = "Novel Plasma Proteins in Nepalese School-aged Children are Associated with a Small Head Size at Birth",
abstract = "Fetal growth restriction increases the risk of poor childhood growth and development and chronic disease in adulthood. Yet, little is known about biological pathways that mediate the long-lasting effects of suboptimal intrauterine growth. We explored the plasma proteome in a cohort of 500 Nepalese children 6-8 years of age to identify plasma proteins associated with multiple anthropometric size indicators at birth. Among 982 proteins analyzed, no proteins differed by birth weight, length, or weight-for-length indicators. However, 25 proteins were differentially abundant in children with a small vs normal head circumference at birth (<-2 vs. ≥-2 z-scores of the WHO growth standards). Angiopoietin-like 6 was 19.4% more abundant and the other 24 proteins were 7-21% less abundant in children with a small vs normal head circumference at birth, adjusted for potential confounders. The less abundant proteins included actins, actin filament organizing proteins (α-actinin, talin, filamin, cofilin, profilin, and vinculin), proteins involved in muscle contraction, and glycolytic enzymes, which were all positively correlated with each other. A novel cluster of childhood plasma proteins involved in angiogenesis and cytoskeleton dynamics was associated with a small head size at birth. The prognostic value of an altered proteomic phenotype remains to be investigated.",
author = "Lee, {Sun Eun} and West, {Keith P.} and Cole, {Robert N.} and Schulze, {Kerry J.} and Wu, {Lee S.F.} and Yager, {James D.} and John Groopman and Parul Christian",
note = "Funding Information: We thank the Johns Hopkins Nutriproteomics Research Team and the Nepal field team (Margia Arguello, Raghothama Chaerkady, Hongie Cui, Lauren R. DeVine, Jaime Johnson, Robert O{\textquoteright}Meally, Steven C. LeClerq, Ashika Nanayakkara-Bind, Hee-Sool Rho, Sudeep Shrestha and Fredrick Van Dyke). We thank Ingo Ruczinski for his proteomics modeling and analytic guidance and C. Conover Talbot, Jr. for assistance with the HUGO gene annotation. This study was supported by the plasma nutriproteomics study through the Assessment of Micronutrient Status by Nutriproteomics grant OPP 5241 from the Bill & Melinda Gates Foundation (Yiwu He, former Senior Program Officer). The cohort study in Nepal from which plasma samples were obtained was supported by the Global Control of Micronutrient Deficiency grant GH 614 [also from the Bill & Melinda Gates Foundation (Ellen Piwoz, Senior Program Officer)]. The original field trial in Nepal from 1999 to 2001 in which mothers of studied children were enrolled was supported by Micronutrients for Health Cooperative Agreement HRN-A-00-97-00015-00 between the Office of Health, Infectious Diseases and Nutrition, US Agency for International Development and the Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health. The Sight and Life Global Nutrition Research Institute provided additional assistance through a Johns Hopkins University/DSM partnership. Publisher Copyright: {\textcopyright} 2018 The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41598-018-24640-4",
language = "English (US)",
volume = "8",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}