Novel patient cell-based HTS assay for identification of small molecules for a lysosomal storage disease

Biochemistry, Genetics and Molecular Biology

• Small Molecule 100%
• High Throughput Screening 100%
• Lysosomal Storage Disease 100%
• Arylsulfatase A 83%
• Metachromatic Leukodystrophy 50%
• Enzyme 33%
• Fibroblast 33%
• Simian Virus 40 33%
• Primary Cell 16%
• Enzyme Activity 16%
• Genetic Disorder 16%
• Lysosome 16%
• Metabolic Disorder 16%
• SV40 Large T Antigen 16%

Immunology and Microbiology

• High Throughput Screening 100%
• Cell Line 40%
• Fibroblast 40%
• Simian Virus 40 40%
• Enzyme Activity 20%
• Lysosome 20%
• Transformed Cell 20%
• SV40 Large T Antigen 20%

Keyphrases

• Colorimetric Substrates 33%
• Nitrocatechol 33%
• Fluorescence Quencher 16%
• Residual Enzymatic Activity 16%
• Bottom Plate 16%
• Assay Miniaturization 16%
• Statistical Parameters 16%