Novel Mutations Involving NF-κB and B-Cell Signaling Pathways in Primary Cutaneous Large B-Cell Lymphoma, Leg-Type and Comparison with Sézary Syndrome

Esther J. Kim; Daniel J. Lewis; Madeleine Duvic

doi:10.1016/j.jid.2017.06.013

Novel Mutations Involving NF-κB and B-Cell Signaling Pathways in Primary Cutaneous Large B-Cell Lymphoma, Leg-Type and Comparison with Sézary Syndrome

Esther J. Kim
, Daniel J. Lewis
, Madeleine Duvic

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Multiple genomic mutations, especially those involving the NF-κB pathway, have been characterized in primary cutaneous large B-cell lymphoma, leg type. However, its genomic profiling remains limited given its rarity. In a recent study, Mareschal et al. performed next-generation sequencing and whole-exome sequencing, identifying new driver genes while also confirming the role of myeloid differentiation primary response gene 88 in the molecular pathogenesis of the disease.

Original language	English (US)
Pages (from-to)	1831-1833
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	137
Issue number	9
DOIs	https://doi.org/10.1016/j.jid.2017.06.013
State	Published - Sep 2017
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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title = "Novel Mutations Involving NF-κB and B-Cell Signaling Pathways in Primary Cutaneous Large B-Cell Lymphoma, Leg-Type and Comparison with S{\'e}zary Syndrome",

abstract = "Multiple genomic mutations, especially those involving the NF-κB pathway, have been characterized in primary cutaneous large B-cell lymphoma, leg type. However, its genomic profiling remains limited given its rarity. In a recent study, Mareschal et al. performed next-generation sequencing and whole-exome sequencing, identifying new driver genes while also confirming the role of myeloid differentiation primary response gene 88 in the molecular pathogenesis of the disease.",

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AU - Lewis, Daniel J.

AU - Duvic, Madeleine

PY - 2017/9

Y1 - 2017/9

N2 - Multiple genomic mutations, especially those involving the NF-κB pathway, have been characterized in primary cutaneous large B-cell lymphoma, leg type. However, its genomic profiling remains limited given its rarity. In a recent study, Mareschal et al. performed next-generation sequencing and whole-exome sequencing, identifying new driver genes while also confirming the role of myeloid differentiation primary response gene 88 in the molecular pathogenesis of the disease.

AB - Multiple genomic mutations, especially those involving the NF-κB pathway, have been characterized in primary cutaneous large B-cell lymphoma, leg type. However, its genomic profiling remains limited given its rarity. In a recent study, Mareschal et al. performed next-generation sequencing and whole-exome sequencing, identifying new driver genes while also confirming the role of myeloid differentiation primary response gene 88 in the molecular pathogenesis of the disease.

UR - https://www.scopus.com/pages/publications/85028362217

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DO - 10.1016/j.jid.2017.06.013

M3 - Comment/debate

C2 - 28843295

AN - SCOPUS:85028362217

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IS - 9

ER -

Novel Mutations Involving NF-κB and B-Cell Signaling Pathways in Primary Cutaneous Large B-Cell Lymphoma, Leg-Type and Comparison with Sézary Syndrome

Abstract

ASJC Scopus subject areas

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