Novel Functional Renal PET Imaging with 18F-FDS in Human Subjects

Rudolf A. Werner; Alvaro A. Ordonez; Julian Sanchez-Bautista; Charles Marcus; Constantin Lapa; Steven P. Rowe; Martin G. Pomper; Jeffrey P. Leal; Martin A. Lodge; Mehrbod S. Javadi; Sanjay K. Jain; Takahiro Higuchi

doi:10.1097/RLU.0000000000002494

Novel Functional Renal PET Imaging with 18F-FDS in Human Subjects

Rudolf A. Werner, Alvaro A. Ordonez, Julian Sanchez-Bautista, Charles Marcus, Constantin Lapa, Steven P. Rowe, Martin G. Pomper, Jeffrey P. Leal, Martin A. Lodge, Mehrbod S. Javadi, Sanjay K. Jain, Takahiro Higuchi

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The novel PET probe 2-deoxy-2-18F-fluoro-d-sorbitol (18F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in 2 human volunteers. 18F-FDS was produced by a simple 1-step reduction from 18F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, 18F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from 18F-FDG, 18F-FDS is virtually available at any PET facility with radiochemistry infrastructure.

Original language	English (US)
Pages (from-to)	410-411
Number of pages	2
Journal	Clinical nuclear medicine
Volume	44
Issue number	5
DOIs	https://doi.org/10.1097/RLU.0000000000002494
State	Published - May 1 2019

Keywords

18F-FDS
2-deoxy-2-18F-fluoro-d-sorbitol
PET
kidney
renal imaging
split renal function

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1097/RLU.0000000000002494

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title = "Novel Functional Renal PET Imaging with 18F-FDS in Human Subjects",

abstract = "The novel PET probe 2-deoxy-2-18F-fluoro-d-sorbitol (18F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in 2 human volunteers. 18F-FDS was produced by a simple 1-step reduction from 18F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, 18F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from 18F-FDG, 18F-FDS is virtually available at any PET facility with radiochemistry infrastructure.",

keywords = "18F-FDS, 2-deoxy-2-18F-fluoro-d-sorbitol, PET, kidney, renal imaging, split renal function",

author = "Werner, {Rudolf A.} and Ordonez, {Alvaro A.} and Julian Sanchez-Bautista and Charles Marcus and Constantin Lapa and Rowe, {Steven P.} and Pomper, {Martin G.} and Leal, {Jeffrey P.} and Lodge, {Martin A.} and Javadi, {Mehrbod S.} and Jain, {Sanjay K.} and Takahiro Higuchi",

year = "2019",

month = may,

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doi = "10.1097/RLU.0000000000002494",

language = "English (US)",

volume = "44",

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journal = "Clinical nuclear medicine",

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AU - Werner, Rudolf A.

AU - Ordonez, Alvaro A.

AU - Sanchez-Bautista, Julian

AU - Marcus, Charles

AU - Lapa, Constantin

AU - Rowe, Steven P.

AU - Pomper, Martin G.

AU - Leal, Jeffrey P.

AU - Lodge, Martin A.

AU - Javadi, Mehrbod S.

AU - Jain, Sanjay K.

AU - Higuchi, Takahiro

PY - 2019/5/1

Y1 - 2019/5/1

N2 - The novel PET probe 2-deoxy-2-18F-fluoro-d-sorbitol (18F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in 2 human volunteers. 18F-FDS was produced by a simple 1-step reduction from 18F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, 18F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from 18F-FDG, 18F-FDS is virtually available at any PET facility with radiochemistry infrastructure.

AB - The novel PET probe 2-deoxy-2-18F-fluoro-d-sorbitol (18F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in 2 human volunteers. 18F-FDS was produced by a simple 1-step reduction from 18F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, 18F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from 18F-FDG, 18F-FDS is virtually available at any PET facility with radiochemistry infrastructure.

KW - 18F-FDS

KW - 2-deoxy-2-18F-fluoro-d-sorbitol

KW - PET

KW - kidney

KW - renal imaging

KW - split renal function

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ER -

Novel Functional Renal PET Imaging with 18F-FDS in Human Subjects

Abstract

Keywords

ASJC Scopus subject areas

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