Novel contrast-enhanced ultrasound evaluation in neonatal hypoxic ischemic injury: Clinical application and future directions

Misun Hwang; Robert M. De Jong; Stephan Herman; Renee Boss; Becky Riggs; Aylin Tekes-Brady; Melissa Spevak; Andrea Poretti; Bruno Soares; Christopher R. Bailey; Emily Dunn; Samuel S. Shin; Shai Shrot; Thierry A.G.M. Huisman

doi:10.1002/jum.14289

Novel contrast-enhanced ultrasound evaluation in neonatal hypoxic ischemic injury: Clinical application and future directions

Misun Hwang, Robert M. De Jong, Stephan Herman, Renee Boss, Becky Riggs, Aylin Tekes-Brady, Melissa Spevak, Andrea Poretti, Bruno Soares, Christopher R. Bailey, Emily Dunn, Samuel S. Shin, Shai Shrot, Thierry A.G.M. Huisman

School of Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Sensitive, specific, and safe bedside evaluation of brain perfusion is key to the early diagnosis, treatment, and improved survival of neonates with hypoxic ischemic injury. Contrast-enhanced ultrasound (US) imaging is a novel imaging technique in which intravenously injected gas-filled microbubbles generate enhanced US echoes from an acoustic impedance mismatch. This article describes contrast-enhanced US imaging in 2 neonates with hypoxic ischemic injury and future directions on developing quantitative contrast-enhanced US techniques for improved characterization of perfusion abnormalities. The importance of studying the temporal evolution of brain perfusion in neonatal hypoxic ischemic injury is also highlighted.

Original language	English (US)
Pages (from-to)	2379-2386
Number of pages	8
Journal	Journal of Ultrasound in Medicine
Volume	36
Issue number	11
DOIs	https://doi.org/10.1002/jum.14289
State	Published - Nov 2017

Keywords

Contrast-enhanced ultrasound
Hypoxic ischemic injury
Microbubbles
Neonates
Neuroimaging
Pediatric ultrasound

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1002/jum.14289

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Hwang, M., De Jong, R. M., Herman, S., Boss, R., Riggs, B., Tekes-Brady, A., Spevak, M., Poretti, A., Soares, B., Bailey, C. R., Dunn, E., Shin, S. S., Shrot, S., & Huisman, T. A. G. M. (2017). Novel contrast-enhanced ultrasound evaluation in neonatal hypoxic ischemic injury: Clinical application and future directions. Journal of Ultrasound in Medicine, 36(11), 2379-2386. https://doi.org/10.1002/jum.14289

Hwang, M, De Jong, RM, Herman, S, Boss, R, Riggs, B, Tekes-Brady, A, Spevak, M, Poretti, A, Soares, B, Bailey, CR , Dunn, E, Shin, SS, Shrot, S & Huisman, TAGM 2017, 'Novel contrast-enhanced ultrasound evaluation in neonatal hypoxic ischemic injury: Clinical application and future directions', Journal of Ultrasound in Medicine, vol. 36, no. 11, pp. 2379-2386. https://doi.org/10.1002/jum.14289

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AU - Spevak, Melissa

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AU - Soares, Bruno

AU - Bailey, Christopher R.

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Novel contrast-enhanced ultrasound evaluation in neonatal hypoxic ischemic injury: Clinical application and future directions

Abstract

Keywords

ASJC Scopus subject areas

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