Novel agents for muscle-invasive and advanced urothelial cancer

Guru Sonpavde, Robert Ross, Thomas Powles, Christopher J. Sweeney, Noah Hahn, Thomas E. Hutson, Matthew D. Galsky, Seth P. Lerner, Cora N. Sternberg

Research output: Contribution to journalShort surveypeer-review

13 Scopus citations


Conventional front-line platinum-based combination chemotherapy yields high response rates but suboptimal long-term outcomes for advanced urothelial cancer. Salvage therapy is an unmet need, with disappointing outcomes. The profusion of novel biological agents offers the promise of improved outcomes. Neoadjuvant therapy before cystectomy for muscle-invasive bladder cancer provides an important paradigm and an interesting approach in developing novel agents. Patients who are not candidates for cisplatin require special attention. A multidisciplinary approach and collaboration among laboratory scientists, oncologists, urologists and radiation oncologists is necessary to make therapeutic advances. Recent and ongoing trials of novel chemotherapeutic and biologic agents are reviewed.

Original languageEnglish (US)
Pages (from-to)937-943
Number of pages7
JournalBJU International
Issue number8
StatePublished - Apr 2008
Externally publishedYes


  • Biological agents
  • Chemotherapy
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Urology


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