Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo

Keyphrases

• Lung Cancer 100%
• Tumorigenesis 100%
• Notch Signaling 100%
• Clonogenic Capacity 100%
• Oncogenesis 60%
• Dominant Negative 40%
• Family Members 40%
• Non-small Cell Lung Cancer (NSCLC) 40%
• NOTCH3 40%
• Notch Pathway 40%
• KRAS G12D 40%
• Notch Family 40%
• Mouse Model 20%
• Lung 20%
• Precursor Lesions 20%
• Tumor Growth 20%
• Secretase 20%
• Human Lung Cancer 20%
• Cancer Cell Lines 20%
• Cellular Compartments 20%
• Lung Tumor 20%
• Transgenic 20%
• Cancer Stem Cells 20%
• Notch Signaling Pathway 20%
• Constitutively Active 20%
• Tumorigenic Potential 20%
• Regulatory Pathways 20%
• Tumor Initiation 20%
• Pathway Activity 20%
• Mastermind 20%
• γ-secretase Inhibitor 20%
• Proliferation Ability 20%
• Clonogenic Potential 20%
• Notch Activity 20%
• Cancer Progenitor Cells 20%
• Global Pathway 20%
• Early-stage Tumor 20%
• Targeted Inhibition 20%
• Anticancer Strategy 20%
• Tumour Precursor 20%
• Genetically Modified Models 20%
• NICD3 20%

Medicine and Dentistry

• In Vitro 100%
• Lung Cancer 100%
• Carcinogenesis 100%
• Notch Signaling 100%
• Notch 83%
• Non Small Cell Lung Cancer 33%
• Secretase 33%
• Neoplasm 16%
• Precursor 16%
• Malignant Neoplasm 16%
• Stem Cell 16%
• Progenitor Cell 16%
• Downregulation 16%
• Signal Transduction 16%
• Tumor Progression 16%
• Upregulation 16%
• Lung Tumor 16%
• Tumor Initiation 16%
• Cell Compartment 16%
• Lung 16%

Biochemistry, Genetics and Molecular Biology

• Carcinogenesis 100%
• Notch Signaling Pathway 100%
• Notch 83%
• Secretase 33%
• KRAS 33%
• Precursor 16%
• Progenitor Cell 16%
• Downregulation 16%
• Upregulation 16%
• Tumor Progression 16%
• Mouse Model 16%
• Anticancer 16%
• Transgenics 16%
• Cancer Stem Cell 16%
• Tumor Initiation 16%