TY - JOUR
T1 - Nosocomial respiratory infections in a rural zambian hospital
AU - Loevinsohn, Gideon
AU - Hardick, Justin
AU - Mehoke, Thomas
AU - Sinywimaanzi, Pamela
AU - Hamahuwa, Mutinta
AU - Fenstermacher, Katherine Z.J.
AU - Shaw-Saliba, Kathryn
AU - Thielen, Peter
AU - Evans, Jared
AU - Bowden, Kenneth
AU - Zudock, Kristina
AU - Sauer, Lauren M.
AU - Monze, Mwaka
AU - Gaydos, Charlotte A.
AU - Rothman, Richard E.
AU - Pekosz, Andrew
AU - Thuma, Philip E
AU - Sutcliffe, Catherine G.
N1 - Funding Information:
Financial support: The work was supported by the National Institute of Allergy and Infectious Diseases contract HHSN272201400007C awarded to the Johns Hopkins Center of Excellence in Influenza Research and Surveillance (JHCEIRS) at the Johns Hopkins University. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not represent the policy or position of NIAID or NIH. The funding agency had no role in the analysis of the data, writing of the manuscript, or the decision to submit the manuscript for publication.
Publisher Copyright:
Copyright © 2021 by The American Society of Tropical Medicine and Hygiene
PY - 2021/9
Y1 - 2021/9
N2 - The burden of nosocomial respiratory infections in rural southern Africa is poorly understood. We established a surveillance program at a rural Zambian hospital to detect influenza-like illness (ILI) and respiratory infections among hospitalized patients and a cohort of healthcare workers (HCWs). Nasopharyngeal specimens from symptomatic patients and HCWs underwent broadly multiplexed molecular testing to detect viruses and atypical bacteria. During 1 year of surveillance, 15 patients (1.7% of admissions) developed ILI more than 48 hours after admission. Among 44 HCWs, 19 (43%) experienced at least one ILI episode, with a total of 31 ILI episodes detected. Respiratory viruses were detected in 45% of patient and 55% of HCW specimens. The cumulative incidence of influenza infection among HCWs over 1 year was 9%. Overall, respiratory viruses were commonly found among patients and HCWs in a rural Zambian hospital with limited infection control infrastructure.
AB - The burden of nosocomial respiratory infections in rural southern Africa is poorly understood. We established a surveillance program at a rural Zambian hospital to detect influenza-like illness (ILI) and respiratory infections among hospitalized patients and a cohort of healthcare workers (HCWs). Nasopharyngeal specimens from symptomatic patients and HCWs underwent broadly multiplexed molecular testing to detect viruses and atypical bacteria. During 1 year of surveillance, 15 patients (1.7% of admissions) developed ILI more than 48 hours after admission. Among 44 HCWs, 19 (43%) experienced at least one ILI episode, with a total of 31 ILI episodes detected. Respiratory viruses were detected in 45% of patient and 55% of HCW specimens. The cumulative incidence of influenza infection among HCWs over 1 year was 9%. Overall, respiratory viruses were commonly found among patients and HCWs in a rural Zambian hospital with limited infection control infrastructure.
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U2 - 10.4269/ajtmh.20-1470
DO - 10.4269/ajtmh.20-1470
M3 - Article
C2 - 34280144
AN - SCOPUS:85115317245
SN - 0002-9637
VL - 105
SP - 818
EP - 821
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 3
ER -