Normothermic orthotopic canine heart homotransplantation

J. D. Whiffen; W. C. Boake; V. L. Gott

doi:10.1016/0022-4804(67)90087-X

Normothermic orthotopic canine heart homotransplantation

J. D. Whiffen, W. C. Boake, V. L. Gott

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A technique for normothermic orthotopic heart transplantation in the adult dog is described in detail. A brief review of the results of the first twenty transplantations performed during the development of the technique is presented. Only once did the transplanted heart fail to perfuse the recipient. One animal survived for 11 days. The known causes of death in hearts transplanted by this technique are discussed. Sudden death due to unknown causes occurred in several animals after twelve hours to 2 1 2 days of excellent homograft heart function. The determination of the exact cause of death of this group of animals will most likely have to await the development of new knowledge of the biochemical behavior of homografted hearts.

Original language	English (US)
Pages (from-to)	421-426
Number of pages	6
Journal	Journal of Surgical Research
Volume	7
Issue number	9
DOIs	https://doi.org/10.1016/0022-4804(67)90087-X
State	Published - Sep 1967

ASJC Scopus subject areas

Surgery

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title = "Normothermic orthotopic canine heart homotransplantation",

abstract = "A technique for normothermic orthotopic heart transplantation in the adult dog is described in detail. A brief review of the results of the first twenty transplantations performed during the development of the technique is presented. Only once did the transplanted heart fail to perfuse the recipient. One animal survived for 11 days. The known causes of death in hearts transplanted by this technique are discussed. Sudden death due to unknown causes occurred in several animals after twelve hours to 2 1 2 days of excellent homograft heart function. The determination of the exact cause of death of this group of animals will most likely have to await the development of new knowledge of the biochemical behavior of homografted hearts.",

author = "Whiffen, {J. D.} and Boake, {W. C.} and Gott, {V. L.}",

year = "1967",

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T1 - Normothermic orthotopic canine heart homotransplantation

AU - Whiffen, J. D.

AU - Boake, W. C.

AU - Gott, V. L.

PY - 1967/9

Y1 - 1967/9

N2 - A technique for normothermic orthotopic heart transplantation in the adult dog is described in detail. A brief review of the results of the first twenty transplantations performed during the development of the technique is presented. Only once did the transplanted heart fail to perfuse the recipient. One animal survived for 11 days. The known causes of death in hearts transplanted by this technique are discussed. Sudden death due to unknown causes occurred in several animals after twelve hours to 2 1 2 days of excellent homograft heart function. The determination of the exact cause of death of this group of animals will most likely have to await the development of new knowledge of the biochemical behavior of homografted hearts.

AB - A technique for normothermic orthotopic heart transplantation in the adult dog is described in detail. A brief review of the results of the first twenty transplantations performed during the development of the technique is presented. Only once did the transplanted heart fail to perfuse the recipient. One animal survived for 11 days. The known causes of death in hearts transplanted by this technique are discussed. Sudden death due to unknown causes occurred in several animals after twelve hours to 2 1 2 days of excellent homograft heart function. The determination of the exact cause of death of this group of animals will most likely have to await the development of new knowledge of the biochemical behavior of homografted hearts.

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Normothermic orthotopic canine heart homotransplantation

Abstract

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