Abstract
Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD.
Original language | English (US) |
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Pages (from-to) | 378-382 |
Number of pages | 5 |
Journal | Brain research |
Volume | 481 |
Issue number | 2 |
DOIs | |
State | Published - Mar 6 1989 |
Keywords
- Dopamine β-hydroxylase
- Immunocytochemistry
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology