Nonrandom involvement of chromosome 4 in the progression of rat prostatic cancer

John T. Lsaacs, Bharati Hukku

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Owing to progression of the original spontaneous Dunning R‐3327 rat prostatic cancer, a large series of transplantable prostatic tumors have been isolated that differ widely in their histological degree of differentiation, growth rate, androgen sensitivity, and metastatic ability. Using these parameters as criteria, the full spectrum of disease progression is represented within this Dunning system of rat prostatic cancers, ranging from slow‐growing, well‐differentiated, androgen‐sensitive, nonmetastatic forms to fast‐growing, anaplastic, androgen‐independent, highly metastatic forms. Cytogenetic analysis of the two least progressionally advanced Dunning cancers (i.e., histologically well‐differentiated, slow‐growing, nonmetastatic variants) demonstrated no structural or numerical chromosomal aberration, suggesting that the initial development of prostatic cancer may not require detectable cytogenetic changes. In contrast, all 16 of the progressionally more advanced Dunning variants analyzed had a series of characteristic structural and/or numerical chromosomal aberrations that minimally involved chromosome 4. This nonrandom involvement of chromosome 4 was consistently observed regardless of whether the karyotype of the cancer was near‐diploid or hyperaneuploid, suggesting that chromosome 4 aberrations are specifically involved in the progression of rat prostatic cancer. In addition, all four variants that were highly metastatic had, besides aberration of chromosome 4, structural aberrations involving chromosomes 1, 2, and 11. Of the 14 variants that did not have a high metastatic ability, only two had a similar aberrations involving chromosomes 1, 2, 4, and 11, suggesting that these specific chromosomal aberrations may be necessary, albeit not sufficient, for a high metastatic ability of rat prostatic cancers.

Original languageEnglish (US)
Pages (from-to)165-188
Number of pages24
JournalThe Prostate
Issue number2
StatePublished - 1988


  • cytogenetic aberrations
  • karyotypic changes

ASJC Scopus subject areas

  • Oncology
  • Urology


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