Nonparametric sequential evaluation of diagnostic biomarkers

Aiyi Liu, Chengqing Wu, Enrique F. Schisterman

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We consider evaluation and comparison of the diagnostic accuracy of biomarkers with continuous test outcomes, possibly correlated due to repeated measurements. We develop nonparametric group sequential testing procedures to evaluate and compare the area of biomarkers under their receiver operating characteristic curves, with either independent or paired test outcomes. These procedures rely on the construction of a two-dimensional statistic of Whitehead (Statist. Med. 1999; 18:2271-2286) so that design methods based on Brownian motion can be applied.

Original languageEnglish (US)
Pages (from-to)1667-1678
Number of pages12
JournalStatistics in Medicine
Issue number10
StatePublished - May 10 2008
Externally publishedYes


  • Biomarkers
  • Correlated U-statistics
  • Correlated measurements
  • Diagnostic tests
  • Interim looks and early stopping

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability


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